Evidence map›Paper›PMID 41640668›Full record

ReviewGenes & diseases2026

Diverse functional roles of miR-128-3p in human diseases: Focus on its roles in human cancer.

Lingzi Zheng, Sheng Yan, Jinling Zhang, Weisen Ning, Xiaoliu Liu, Xiaomei Wang, Ling Hu

Abstract readReview
In one paragraph

Review in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lingzi ZhengTianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei 430064, China.
Sheng YanTianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei 430064, China.
Jinling ZhangWuhan Fourth Hospital, Wuhan Orthopedic Hospital, Wuhan 430033, China.
Weisen NingCollege of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei 430065, China.
Xiaoliu LiuCollege of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei 430065, China.
Xiaomei WangTianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei 430064, China.
Ling HuTianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei 430064, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The microRNA known as miR-128-3p demonstrates widespread tissue-specific expression with its genetic locus situated on human chromosome 2 (2q21.3), and is a multifunctional regulator with tissue-specific expression patterns that critically influences cellular homeostasis and disease pathogenesis. By engaging with the 3' untranslated region (3' UTR) of target mRNA molecules, miR-128-3p exquisitely modulates gene expression levels, thereby orchestrating cellular proliferation, immune responses, metabolic equilibrium, and tumorigenesis. Studies on miR-128-3p in different cancers have revealed diverse expression patterns and functional roles. Intriguingly, due to its ability to target multiple genes and signaling pathways, as well as being regulated by various genes themselves, miR-128-3p exhibits both tumor-suppressive and oncogenic effects under neoplastic conditions. This review summarizes the expression patterns and complex regulatory mechanisms of miR-128-3p across various cancers. A profound understanding of the significance and regulation of miR-128-3p in cancer will drive the development of innovative therapeutic strategies using this molecule for combating human cancer and immune-related disorders.

Indexed as

CancerDiagnostic markersMicroRNAMiR-128-3pPathway

Identifiers

PMID41640668
PMCPMC12865633

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.