ArticleFrontiers in nutrition2025
Nutritional practices and impact of feeding adequacy on clinical outcomes in Chinese respiratory intensive care units patients: a prospective observational study (ORIENT study).
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Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04958447 (Nutritional Management in Respiratory Critically Ill Patients -an Observational Study in Mainland China), which is not on this map. Not yet cited in PubMed.
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Nutritional Management in Respiratory Critically Ill Patients -an Observational Study in Mainland China
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75 authors.
Xu Huang *National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Yafei Wang *Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Shuang Geng *Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ying Liang *Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
Fan GaoMedical Research & Biometrics Center National Center for Cardiovascular Diseases Cardiovascular Institute & Fuwai Hospital, The Chinese Academy of Medical Sciences, Beijing, China.
Tiantian WangMedical Research & Biometrics Center National Center for Cardiovascular Diseases Cardiovascular Institute & Fuwai Hospital, The Chinese Academy of Medical Sciences, Beijing, China.
Huagen ZhangDepartment of Respiratory and Critical Care Medicine, Meizhou People's Hospital, Meizhou, China.
Jie FangDepartment of Respiratory and Critical Care Medicine, Dezhou People's Hospital, Dezhou, China.
Chu WangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Xiu GuDepartment of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Jingping YangDepartment of Respiratory and Critical Care Medicine, Inner Mongolia Baogang Hospital, Baotou, China.
Zhenshun ChengDepartment of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Chun LiuDepartment of Respiratory and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.
Wei LeiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
Xingang HuDepartment of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
Hong LuoDepartment of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, China.
Huaihai FanRespiratory ICU, Tai An City Central Hospital, Tai An, China.
Yunhui ZhangDepartment of Respiratory and Critical Care Medicine, The First People's Hospital of Yunnan Province, Kunming, China.
Guoqiang LiIntensive Care Unit, Medical Center of Chinese People's Armed Police Force, Tianjin, China.
Qingguo DiDepartment of Respiratory and Critical Care Medicine, Cangzhou Central Hospital, Cangzhou, China.
Lihua XingDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yuanyuan LiDepartment of Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, China.
Jin TongDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Lin ChenDepartment of Respiratory and Critical Care Medicine, Sichuan Provincial People's Hospital, Chengdu, China.
Wei SunDepartment of Respiratory and Critical Care Medicine, No.2 People's Hospital of Fuyang City, Fuyang, China.
Liang ChenDepartment of Respiratory and Critical Care Medicine, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Nanjing, China.
Shengyu WangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Medical University, Xi'an, China.
Shaojun LiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Jianhua LiuDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, Shijiazhuang, China.
Hao QinDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Second Military Medical University, Shanghai, China.
Xiaohua QiuDepartment of Respiratory and Critical Care Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Zhuang MaDepartment of Respiratory and Critical Care Medicine, The General Hospital of Northern Theater Command, Shenyang, China.
Yanxia LiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Hongbin ZhaoDepartment of Respiratory and Critical Care Medicine, Dali Bai Autonomous Prefecture People's Hospital, Dali, China.
Rongzhang LiangDepartment of Respiratory and Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.
Li WangDepartment of Respiratory and Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Peng GaoDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, China.
Linli SangDepartment of Respiratory and Critical Care Medicine, Northern Jiangsu People's Hospital, Yangzhou, China.
Dan LiDepartment of Respiratory and Critical Care Medicine, The First Hospital of Jilin University, Changchun, China.
Pengguo HouDepartment of Respiratory and Critical Care Medicine, The Third People's Hospital of Datong, Datong, China.
Xiuwei ZhangDepartment of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Dongsheng WangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of USTC (University of Science and Technology of China), Hefei, China.
Ling ZhengDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Feng HuaDepartment of Respiratory and Critical Care Medicine, Huzhou Central Hospital, Huzhou, China.
Jing JiangDepartment of Respiratory and Critical Care Medicine, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Xiaoyan LiDepartment of Respiratory and Critical Care Medicine, Shanxi Bethune Hospital, Taiyuan, China.
Qingrong NieDepartment of Respiratory and Critical Care Medicine, Beijing Fangshan Liangxiang Hospital, Beijing, China.
Hongwen ZhaoDepartment of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China.
Chuncai HuangIntensive Care Unit, The Second Hospital of Tianjin Medical University, Tianjin, China.
Yingqun JiDepartment of Respiratory and Critical Care Medicine, East Hospital Affiliated To Tongji University, Shanghai, China.
Hong YuDepartment of Respiratory and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
Liqiang SongDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Air Force Military Medical University, Xi'an, China.
Ju JinDepartment of Respiratory and Critical Care Medicine, The Second People's Hospital of Wuhu, Wuhu, China.
Ning LiDepartment of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, China.
Weisheng QianDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of AirForce Military Medical University, Xi'an, China.
Jingwu ZengDepartment of Respiratory and Critical Care Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, China.
Liang ChenDepartment of Respiratory and Critical Care Medicine, Beijing Jingmei Group General Hospital, Beijing, China.
Juan SunDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Wei HeDepartment of Respiratory and Critical Care Medicine, The Central Hospital Affiliated to Shenyang Medical College, Shenyang, China.
Shuhong GuanDepartment of Respiratory and Critical Care Medicine, The First People's Hospital of Changzhou, Changzhou, China.
Shukun ChaiDepartment of Respiratory and Critical Care Medicine, Shijiazhuang People's Hospital, Shijiazhuang, China.
Siming HuDepartment of Respiratory and Critical Care Medicine, Suzhou Municipal Hospital, Suzhou, China.
Guanhua LiDepartment of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin, China.
Junjie LiDepartment of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Hongying JiangDepartment of Respiratory and Critical Care Medicine, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China.
Xuefeng ZhongDepartment of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China.
Jiashu LiDepartment of Respiratory and Critical Care Medicine, The First Hospital of Lianyungang, Lianyungang, China.
Jing ZhaoDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Wei DuDepartment of Respiratory and Critical Care Medicine, General Hospital of Southern Theater Command, PLA, Guangzhou, China.
Jiegen ZhangDepartment of Respiratory and Critical Care Medicine, Zhuozhou City Hospital, Zhuozhou, China.
Zhiliang LiuDepartment of Respiratory and Critical Care Medicine, Tangshan Center Hospital, Tangshan, China.
Arthur van ZantenDepartment of Intensive Care Medicine & Research, Gelderse Vallei Hospital, Ede, Netherlands.
Ye TianNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Ying CaiNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Qingyuan ZhanNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The current status of nutritional support for patients in Respiratory ICU across mainland China remains inadequately characterized. This multi-center study, conducted in RICUs, was designed to investigate nutritional practices in this specific patient population, focusing on initiation timing, energy/protein adequacy, and associations with clinical outcomes. Methods: A prospective, observational study enrolled 1,026 patients (ICU stay >48 h) across 68 Chinese RICUs. We analyzed EN initiation rates (24 h/48 h), caloric/protein intake adequacy during the first 7 days, and outcomes via multivariable Cox regression. Results: EN initiation occurred in 36.8% (24 h) and 43.4% (48 h) of patients. Excluding patients who could take oral food, the proportion of patients who started EN within 24 and 48 h increased to 86.9 and 95.3%. Among 499 EN-fed patients, 26.1% developed EN complications. Caloric analysis ( Conclusion: This multicenter study demonstrates optimal early EN initiation rates in Chinese RICUs. Energy overfeeding was associated with increased mortality risk only in patients >50 years and non-social infections risk, whereas protein adequacy showed no outcome associations. Protocolized EN delivery balancing adequacy and overfeeding risks is urgently needed in RICUs. Clinical trial registration: Identifier, NCT04958447.
Indexed as
energy intakeenteral nutritionfeeding adequacymortalitynutritional statusRICU
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NCT04958447ClinicalTrials.gov
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