SynthesisFrontiers in nutrition2025
Comparative effects of different types of soy products on glycemic control and insulin sensitivity: a network meta-analysis of randomized controlled trials.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Fruits, Vegetables, and Legumes: Harnessing the Gut-Kidney Axis in Hypertensive Chronic Kidney Disease.Foods (Basel, Switzerland) · 2026Review
- Article
- Selected Nutraceuticals in Metabolic Syndrome: Molecular Mechanisms and Clinical Implications.Biomedicines · 2026Review
- Associations between dietary isoflavones and subtypes intakes and the risk of new-onset of type 2 diabetes mellitus in Chinese adults: a prospective cohort study from the Chinese health and nutrition survey.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims: Accumulating evidence has demonstrated the benefits of soy and its extracts on glycemic control and insulin sensitivity. We hypothesized that different soy components might exhibit differentiated blood glucose and insulin sensitivity regulation effects. The goal of this network meta-analysis of randomized clinical trials (RCTs) was to estimate and rank the relative effects of soy and its extracts on glycemic control and insulin sensitivity. Methods: We performed a strategic literature search of PubMed, Embase, and the Cochrane Library for relevant RCTs. Random-effects network meta-analyses, ranking analyses based on surface under the cumulative ranking curves (SUCRAs), and sensitivity analyses based on potential sources of heterogeneity were performed. We registered the study protocol at PROSPERO (no. CRD42022345831). Results: Sixty-one RCTs enrolling 4,744 participants were included in the quantitative analysis. In random-effects network meta-analyses. Whole soy was ranked as the best diet (SUCRA: 91.0%) regarding fasting glucose-lowering effects, with isolated isoflavones was ranked as second (SUCRA: 79.1%). For fasting insulin regulation, the best soy component choices was whole soy (SUCRA: 95.4%) and isolated isoflavones (SUCRA: 74.7%). For HOMA-IR regulation, the best soy component choices was whole soy (SUCRA: 83.4%) and Soy protein + isoflavones (SUCRA: 83.3%). No soy products showed significant effect on regulating glycated HbA1c. Conclusions: These findings highlight that different soy components exhibit distinct effects on regulating blood glucose and insulin sensitivity. In this network meta-analysis, whole soy and isolated isoflavones were identified as potentially superior choices for improving blood glucose control and insulin sensitivity compared with other soy products. Systematic review registration: http://www.crd.york.ac.uk/ PROERO, identifier CRD42022345831.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.