Evidence map›Paper›PMID 41640800›Full record

ArticleCHEST critical care2025

A Computable Electronic Health Record ARDS Classifier and the Association Between the

V Eric Kerchberger, J Brennan McNeil, Neil Zheng, Diana Chang, Carrie M Rosenberger, Angela J Rogers, Julie A Bastarache, QiPing Feng, Wei-Qi Wei, Lorraine B Ware

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Article in CHEST critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

  1. Observational
4 · The record

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5 · Who and what money

Authors and funding

10 authors.

V Eric KerchbergerDepartment of Medicine (V. E. K., J. B. M., J. A. B., Q. F., L. B. W.), the Department of Biomedical Informatics (V. E. K., N. Z., W.-Q. W.), Vanderbilt University Medical Center; the Department of Cell and Developmental Biology (J. A. B.), the Department of Pathology, Microbiology and Immunology (J. A. B., L. B. W.), Vanderbilt University, Nashville; Quillen College of Medicine (J. B. M.), East Tennessee State University, Johnson City, TN; Brigham and Women's Hospital (N. Z.), Boston, MA; Genentech, Inc. (D. C., C. M. R.), South San Francisco; and the Department of Medicine (A. J. R.), Stanford University, Palo Alto, CA.
J Brennan McNeilDepartment of Medicine (V. E. K., J. B. M., J. A. B., Q. F., L. B. W.), the Department of Biomedical Informatics (V. E. K., N. Z., W.-Q. W.), Vanderbilt University Medical Center; the Department of Cell and Developmental Biology (J. A. B.), the Department of Pathology, Microbiology and Immunology (J. A. B., L. B. W.), Vanderbilt University, Nashville; Quillen College of Medicine (J. B. M.), East Tennessee State University, Johnson City, TN; Brigham and Women's Hospital (N. Z.), Boston, MA; Genentech, Inc. (D. C., C. M. R.), South San Francisco; and the Department of Medicine (A. J. R.), Stanford University, Palo Alto, CA.
Neil ZhengDepartment of Medicine (V. E. K., J. B. M., J. A. B., Q. F., L. B. W.), the Department of Biomedical Informatics (V. E. K., N. Z., W.-Q. W.), Vanderbilt University Medical Center; the Department of Cell and Developmental Biology (J. A. B.), the Department of Pathology, Microbiology and Immunology (J. A. B., L. B. W.), Vanderbilt University, Nashville; Quillen College of Medicine (J. B. M.), East Tennessee State University, Johnson City, TN; Brigham and Women's Hospital (N. Z.), Boston, MA; Genentech, Inc. (D. C., C. M. R.), South San Francisco; and the Department of Medicine (A. J. R.), Stanford University, Palo Alto, CA.
Diana ChangDepartment of Medicine (V. E. K., J. B. M., J. A. B., Q. F., L. B. W.), the Department of Biomedical Informatics (V. E. K., N. Z., W.-Q. W.), Vanderbilt University Medical Center; the Department of Cell and Developmental Biology (J. A. B.), the Department of Pathology, Microbiology and Immunology (J. A. B., L. B. W.), Vanderbilt University, Nashville; Quillen College of Medicine (J. B. M.), East Tennessee State University, Johnson City, TN; Brigham and Women's Hospital (N. Z.), Boston, MA; Genentech, Inc. (D. C., C. M. R.), South San Francisco; and the Department of Medicine (A. J. R.), Stanford University, Palo Alto, CA.
Carrie M RosenbergerDepartment of Medicine (V. E. K., J. B. M., J. A. B., Q. F., L. B. W.), the Department of Biomedical Informatics (V. E. K., N. Z., W.-Q. W.), Vanderbilt University Medical Center; the Department of Cell and Developmental Biology (J. A. B.), the Department of Pathology, Microbiology and Immunology (J. A. B., L. B. W.), Vanderbilt University, Nashville; Quillen College of Medicine (J. B. M.), East Tennessee State University, Johnson City, TN; Brigham and Women's Hospital (N. Z.), Boston, MA; Genentech, Inc. (D. C., C. M. R.), South San Francisco; and the Department of Medicine (A. J. R.), Stanford University, Palo Alto, CA.
Angela J RogersDepartment of Medicine (V. E. K., J. B. M., J. A. B., Q. F., L. B. W.), the Department of Biomedical Informatics (V. E. K., N. Z., W.-Q. W.), Vanderbilt University Medical Center; the Department of Cell and Developmental Biology (J. A. B.), the Department of Pathology, Microbiology and Immunology (J. A. B., L. B. W.), Vanderbilt University, Nashville; Quillen College of Medicine (J. B. M.), East Tennessee State University, Johnson City, TN; Brigham and Women's Hospital (N. Z.), Boston, MA; Genentech, Inc. (D. C., C. M. R.), South San Francisco; and the Department of Medicine (A. J. R.), Stanford University, Palo Alto, CA.
Julie A BastaracheDepartment of Medicine (V. E. K., J. B. M., J. A. B., Q. F., L. B. W.), the Department of Biomedical Informatics (V. E. K., N. Z., W.-Q. W.), Vanderbilt University Medical Center; the Department of Cell and Developmental Biology (J. A. B.), the Department of Pathology, Microbiology and Immunology (J. A. B., L. B. W.), Vanderbilt University, Nashville; Quillen College of Medicine (J. B. M.), East Tennessee State University, Johnson City, TN; Brigham and Women's Hospital (N. Z.), Boston, MA; Genentech, Inc. (D. C., C. M. R.), South San Francisco; and the Department of Medicine (A. J. R.), Stanford University, Palo Alto, CA.
QiPing FengDepartment of Medicine (V. E. K., J. B. M., J. A. B., Q. F., L. B. W.), the Department of Biomedical Informatics (V. E. K., N. Z., W.-Q. W.), Vanderbilt University Medical Center; the Department of Cell and Developmental Biology (J. A. B.), the Department of Pathology, Microbiology and Immunology (J. A. B., L. B. W.), Vanderbilt University, Nashville; Quillen College of Medicine (J. B. M.), East Tennessee State University, Johnson City, TN; Brigham and Women's Hospital (N. Z.), Boston, MA; Genentech, Inc. (D. C., C. M. R.), South San Francisco; and the Department of Medicine (A. J. R.), Stanford University, Palo Alto, CA.
Wei-Qi WeiDepartment of Medicine (V. E. K., J. B. M., J. A. B., Q. F., L. B. W.), the Department of Biomedical Informatics (V. E. K., N. Z., W.-Q. W.), Vanderbilt University Medical Center; the Department of Cell and Developmental Biology (J. A. B.), the Department of Pathology, Microbiology and Immunology (J. A. B., L. B. W.), Vanderbilt University, Nashville; Quillen College of Medicine (J. B. M.), East Tennessee State University, Johnson City, TN; Brigham and Women's Hospital (N. Z.), Boston, MA; Genentech, Inc. (D. C., C. M. R.), South San Francisco; and the Department of Medicine (A. J. R.), Stanford University, Palo Alto, CA.
Lorraine B WareDepartment of Medicine (V. E. K., J. B. M., J. A. B., Q. F., L. B. W.), the Department of Biomedical Informatics (V. E. K., N. Z., W.-Q. W.), Vanderbilt University Medical Center; the Department of Cell and Developmental Biology (J. A. B.), the Department of Pathology, Microbiology and Immunology (J. A. B., L. B. W.), Vanderbilt University, Nashville; Quillen College of Medicine (J. B. M.), East Tennessee State University, Johnson City, TN; Brigham and Women's Hospital (N. Z.), Boston, MA; Genentech, Inc. (D. C., C. M. R.), South San Francisco; and the Department of Medicine (A. J. R.), Stanford University, Palo Alto, CA.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Applying Innovative Lung Mapping Strategies to Understand Alveolar Capillary Barrier Permeability in ARDSR35HL150783 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2020 to 2026
$4.6M
Targeting Residual ASCVD Risk by Integrating Genetics and Clinical DataR01HL171809 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Qiping Feng, Wei-Qi Wei · 2024 to 2026
$2.6M
Haptoglobin 2 variant and endothelial glycocalyx shedding in sepsis-induced ARDSR01HL158906 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARE, LORRAINE B · 2021 to 2024
$2.3M
Hemoglobin in ARDS: a novel mediator of aveolar epithelial cell dysfunctionR01HL126671 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BASTARACHE, JULIE ANNE · 2015 to 2019
$2.0M
Mechanisms of organ dysfunction and recovery in the Acetaminophen and Ascorbate Trial in SepsisR01HL164937 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARE, LORRAINE B · 2022 to 2025
$1.7M
Systematically screening and validating drug repurposing candidates for Alzheimer's Disease and Related DementiasR56AG084550 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FENG, QIPING, WEI, WEI-QI · 2024 to 2024
$875k
Tissue-specific functional genomics in the acute respiratory distress syndromeK01HL157755 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KERCHBERGER, VERN ERIC · 2021 to 2025
$845k
NCATS NIH HHS UL1 TR002243NHLBI NIH HHS K01 HL157755NHLBI NIH HHS R01 HL126671NHLBI NIH HHS R01 HL158906NHLBI NIH HHS R01 HL164937NHLBI NIH HHS R01 HL171809NHLBI NIH HHS R35 HL150783NIA NIH HHS R56 AG084550
6 · The paper itself

Abstract

backgroundLarge population-based DNA biobanks linked to electronic health records (EHRs) may provide novel opportunities to identify genetic drivers of ARDS. RESEARCH QUESTION: Can a computerized algorithm identify ARDS in a large EHR biobank database, and can this be used to identify ARDS genetic risk factors? STUDY DESIGN AND

methodsWe developed a classifier algorithm to identify a diagnosis of ARDS as identified from the electronic health record (EHR-ARDS) using diagnostic billing codes, laboratory test results, and chest radiography report text. The classifier model performance was evaluated against investigator-adjudicated ARDS using standard classification metrics including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the Cohen κ value. After confirming acceptable classifier performance, we evaluated the association between EHR-ARDS and the

resultsWe included 2,795 patients from VALID and 9,025 hospitalized participants from BioVU. EHR-ARDS showed moderate agreement with investigator-adjudicated ARDS (VALID: sensitivity, 0.86; specificity, 0.70; PPV, 0.49; NPV, 0.93; and k, 0.45; BioVU: sensitivity, 0.94; specificity, 0.81; PPV, 0.66; NPV, 0.97; and k, 0.67). We observed a significant age-gene interaction effect for EHR-ARDS in VALID: among older patients, rs35705950 was associated with increased EHR-ARDS risk (OR, 1.37; 95% CI, 1.05-1.78;

interpretationThe

Indexed as

ARDSelectronic health recordsgenetic risk factorsinteraction analysisMUC5B gene

Identifiers

PMID41640800
PMCPMC12867120

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.