Evidence map›Paper›PMID 41641103›Full record

ReviewiScience2026

Connections between physics and metabolism in brain functions.

Fanny Mochel, Alfonso de Oyarzábal Sanz, Leticia Pías Peleteiro, Juliana Ribeiro-Constante, Patricia Bassereau, Kevin Chalut, Laurent Cognet, Leroy Cronin, Stuart Hameroff, Francisco J López-Murcia and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fanny MochelINSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC University Paris 06 UMR S 1127, Institut du Cerveau, ICM, Paris, France.
Alfonso de Oyarzábal SanzNeurometabolic Unit. Neurology Department. Institut de Recerca Sant Joan de Déu, CIBERER and MetabERN, Hospital Sant Joan de Déu, Barcelona, Spain.
Leticia Pías PeleteiroNeurometabolic Unit. Neurology Department. Institut de Recerca Sant Joan de Déu, CIBERER and MetabERN, Hospital Sant Joan de Déu, Barcelona, Spain.
Juliana Ribeiro-ConstanteNeurometabolic Unit. Neurology Department. Institut de Recerca Sant Joan de Déu, CIBERER and MetabERN, Hospital Sant Joan de Déu, Barcelona, Spain.
Patricia BassereauInstitut Curie, Université PSL, Sorbonne Université, CNRS UMR 168, Laboratoire Physico-Chimie Curie, Paris, France.
Kevin ChalutWellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK.
Laurent CognetLaboratoire Photonique Numérique et Nanosciences, Université de Bordeaux, 33400 Talence, France.
Leroy CroninSchool of Chemistry, The University of Glasgow, University Avenue, G12 8QQ Glasgow, UK.
Stuart HameroffDepartments of Anesthesiology and Psychology, Banner-University Medical Center, Center for Consciousness Studies, The University of Arizona, Tucson, AZ, USA.
Francisco J López-MurciaDepartment of Pathology and Experimental Therapy, Institute of Neurosciences, University of Barcelona, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Eva K PillaiCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Marta Sales-PardoDepartment of Chemical Engineering, Universitat Rovira I Virgili, Tarragona, Spain.
Anne StraubeCentre for Mechanochemical Cell Biology and Warwick Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
Adrien HallouKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Angeles Garcia-CazorlaNeurometabolic Unit. Neurology Department. Institut de Recerca Sant Joan de Déu, CIBERER and MetabERN, Hospital Sant Joan de Déu, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in molecular biology have shaped our understanding of cellular biology. Yet, this molecular-centric approach has overshadowed the role of physical processes governing cellular homeostasis. In genetic disorders, particularly inherited metabolic diseases, phenotypic heterogeneity cannot solely be explained by genetic variants. Mechanical properties of cells and tissues may account for this variability, given the interplay between biological and physical cues in metabolic regulations. In July 2024, we organized an international symposium with world experts in physics, chemistry, and neurobiology to explore the physical regulation of brain metabolism in health and disease. Topics included mechanotransduction in neurodevelopment and brain aging, the physics of neurotransmission and cellular trafficking, and emerging methods to model cellular metabolism, analyze single-cell mechanical and transcriptional signals, and track nanoparticles in intact brain tissue. This effort aims to foster an interdisciplinary framework for neuroscience and train scientists across disciplines, while integrating art to stimulate creativity and integrative thinking.

Indexed as

BiophysicsCell biologyHuman metabolism

Identifiers

PMID41641103
PMCPMC12865549

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.