ArticleWorld journal of psychiatry2026
L-shaped association between fasting blood glucose and comorbid anxiety in Chinese patients with first-episode untreated major depressive disorder.
Article in World journal of psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMajor depressive disorder (MDD) frequently presents with comorbid anxiety, complicating treatment outcomes. While glucose metabolism dysfunction has been linked to both depression and anxiety, the specific relationship between fasting blood glucose (FBG) levels and comorbid anxiety in MDD remains inadequately characterized.
aimTo investigate the relationship between FBG and comorbid anxiety in individuals with first-episode untreated MDD.
methodsThis cross-sectional study included 1718 participants with first-episode untreated MDD. Demographic, anthropometric, and biochemical parameters, including FBG, were collected. Depressive and anxiety symptoms were assessed using the 17-item Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale, respectively. Potential non-linear relationships were examined using smoothing curves and two-piecewise logistic regression analysis.
resultsThe betweengroup comparison indicated that patients comorbid with anxiety have significantly higher FBG levels than those without comorbid anxiety (
conclusionOur results suggest an L-shaped non-linear association: Lower FBG correlates with elevated comorbid anxiety risk in Chinese Han first-episode untreated MDD patients, particularly when FBG is below 4.8 mmol/L.
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