ArticleWorld journal of psychiatry2026
Correlation of frontal lobe electroencephalogram asymmetry and cognitive prognosis in schizophrenia.
Article in World journal of psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSchizophrenia is a debilitating psychiatric disorder marked by cognitive impairments that affect functional outcomes. However, the neurobiological underpinnings of these deficits, particularly in relation to frontal lobe electroencephalography (EEG) asymmetry, remain insufficiently understood. This study aims to examine the association between frontal lobe EEG asymmetry and cognitive prognosis in individuals with schizophrenia.
aimTo explore the association between frontal lobe EEG asymmetry and cognitive prognosis in patients with schizophrenia.
methodsThis retrospective study analyzed data from 104 patients with schizophrenia who received treatment between 2020 and 2023. The patients were divided into good (
resultsNotable differences in EEG asymmetry were observed under eyes-open conditions. Patients in the good cognitive prognosis group demonstrated mean eyes-open frontal alpha asymmetry values of -0.09 at F4-F3 and -0.155 at F6-F5, whereas those in the poor prognosis group showed values of -0.10 and -0.183, respectively. These differences were significantly correlated with cognitive outcomes (
conclusionThe findings suggest that eyes-open frontal EEG asymmetry and FPN connectivity are associated with cognitive prognosis in individuals with schizophrenia.
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