ArticleWorld journal of psychiatry2026
Correlation of anxiety/depression status with stress-related markers and cancer-related fatigue in patients with colon cancer.
Article in World journal of psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAnxiety and depression are significant contributors to adverse outcomes in patients with colon cancer (CC). Therefore, investigating the key determinants of this psychological distress in such patients is essential.
aimTo examine the correlation of anxiety/depression status with stress-related markers and cancer-related fatigue (CRF), along with associated risk factors in patients with CC.
methodsThe study enrolled 120 patients with CC treated at the Affiliated Yongchuan Hospital of Chongqing Medical University between February 2022 and February 2025. Initially, patients' anxiety [Self-Rating Anxiety Scale (SAS)] and depression [Self-Rating Depression Scale (SDS)] status were assessed first and then stratified into the anxiety/depression group (
resultsThe analysis revealed prevalence rates of 30.00% for anxiety and 38.33% for depression among the 120 patients with CC, of whom 51.67% exhibited either condition, and 16.67% showed comorbidity. Both groups showed an initial increase in HSP70, CRP, and BFI-C followed by a decrease compared with those at T0, with the anxiety/depression group exhibiting markedly higher levels of HSP70, CRP, and BFI-C at T1 and T2. Subsequent correlation analysis revealed strong positive correlations between SAS and SDS scores and HSP70, CRP, and BFI-C concentrations. Univariate analysis identified sex, age, marital status, monthly household income, tumor stage, and comorbidities as factors closely associated with anxiety or depression. Multivariate analysis further established female sex [odds ratio (OR) = 2.755], age ≥ 60 years (OR = 2.649), and advanced tumor stage (III-IV, OR = 2.349) as independent predictors of anxiety or depression in patients with CC.
conclusionA subset of patients with CC exhibits anxiety and depressive symptoms, which are significantly positively correlated with stress-related markers and CRF. Moreover, patients with CC, female patients, those aged 60 years or older, and patients diagnosed with stage III-IV tumors are more prone to anxiety or depression.
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