Evidence map›Paper›PMID 41641784›Full record

ArticleMolecular plant pathology2026

Glycoside Hydrolase CaGH17-12 Contributes to Phytophthora Blight Resistance by Activating the Production of Reactive Oxygen Species and Jasmonic Acid Signalling in Pepper.

Fengqing Cheng, Shuangxia Luo, Haoqian Li, Yue Tang, Yuexin Li, Xiaofan Chang, Pengfei Qing, Na Li, Shuxing Shen, Lisong Ma and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular plant pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fengqing ChengKey Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding, China.
Shuangxia LuoKey Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding, China.
Haoqian LiKey Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding, China.
Yue TangKey Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding, China.
Yuexin LiKey Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding, China.
Xiaofan ChangKey Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding, China.
Pengfei QingKey Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding, China.
Na LiKey Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding, China.
Shuxing ShenKey Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding, China.
Lisong MaKey Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding, China.ORCID 0000-0001-9288-869X
Xueping ChenKey Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding, China.ORCID 0000-0002-1358-6923

Funding

National Key Research and Development Program of China 2023YFD1600202the S&T Program of Hebei 21326309D
6 · The paper itself

Abstract

Glycoside hydrolase family 17 (GH17) plays a critical role in degrading pathogen cell walls and is involved in plant defence responses against biotic stress. However, the functional roles of GH17 members in pepper in response to Phytophthora capsici, the causal agent of Phytophthora blight, remain unexplored. In this study, a total of 55 CaGH17 genes were identified in the pepper genome and classified into three distinct subfamilies based on phylogenetic relationships. Transcriptome analysis of both the resistant cultivar 17-p63 and the susceptible cultivar 16-217 inoculated with P. capsici at multiple time points revealed that CaGH17-12 exhibited markedly increased expression in the resistant cultivar, while no significant changes were observed in the susceptible cultivar at 60 h post-inoculation. Yeast secretion trap and subcellular localisation assays indicated that CaGH17-12 is secreted into the apoplast. The purified CaGH17-12 protein, expressed in yeast, exhibited β-glucan hydrolase activity, confirming its enzymatic function. Virus-induced gene silencing of CaGH17-12 significantly increased susceptibility to P. capsici, confirming its role in mediating Phytophthora blight resistance. CaGH17-12-silenced pepper plants exhibited reduced expression of jasmonic acid (JA)-related and reactive oxygen species (ROS)-associated genes. Moreover, exogenous application of β-glucan oligosaccharides, the putative hydrolytic products of CaGH17-12, induced pepper resistance to P. capsici by enhancing the production of ROS and activating the expression of defence-related genes. Taken together, these findings identified and characterised the CaGH17 gene family in pepper, highlighting the potential role of CaGH17-12 in conferring resistance to P. capsici through modulation of ROS accumulation and JA signalling.

Indexed as

CapsicumCyclopentanesDisease ResistanceGlycoside HydrolasesOxylipinsPhytophthoraPlant DiseasesReactive Oxygen SpeciesGene Expression Regulation, PlantPhylogenyPlant ProteinsSignal TransductionCyclopentanesGlycoside Hydrolasesjasmonic acidOxylipinsPlant ProteinsReactive Oxygen Speciesdisease resistanceGH17 gene familyoligosaccharidepepperPhytophthora capsiciβ‐Glucan

Identifiers

PMID41641784
PMCPMC12874489

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.