ArticleAging cell2026
Sex Differences in Associations Between Adversity and Biological Ageing.
Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Socioeconomic inequalities in functional ageing trajectories in England and Canada: A comparative longitudinal cohort study.PLoS medicine · 2026Article
- Neurodevelopmental effects of early life stress: PFC and cognition.Neuroscience and biobehavioral reviews · 2026Review
- Sex-Dependent Integration of Symptoms and Functional Vulnerability in Interstitial Lung Disease: eurILDreg Study.Respiration; international review of thoracic diseases · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Adverse events across the life course have been linked to older biological ageing profiles. Whether these associations differ between males and females, and whether such differences depend on adversity occurring in childhood, adulthood or both periods, remains unclear. In 153,557 UK Biobank participants aged 40-69 years, we assessed associations of childhood and/or adulthood adversity with metabolomic ageing, frailty, telomere length and grip strength. Sex differences were evaluated using stratified analyses and sex-by-adversity interaction tests. Exposure to adversity in childhood and/or adulthood was reported by 64.6% of males and 69.6% of females. Childhood adversity was associated with multiple ageing markers primarily in females, including a metabolite-predicted age exceeding chronological age, greater frailty, shorter telomeres and weaker grip strength. Adulthood adversity was more strongly associated with certain ageing markers in males, particularly greater frailty and weaker grip strength. This divergence in sex-specific associations between childhood and adulthood exposure was consistent across several markers, with statistically significant sex-by-adversity interactions for frailty and grip strength. In this large, population-based sample, the timing of adversity, distinguishing childhood from adulthood, shaped whether females or males showed stronger associations with biological ageing markers. These findings suggest that sex differences in biological ageing profiles may partly reflect distinct sensitive periods of vulnerability, highlighting the importance of considering both sex and timing of exposure to adversity when examining links between adversity and biological ageing.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.