Observational studyCritical care medicine2026
Early Measurement of Quadriceps Response to Neuromuscular Electrical Stimulation to Identify Future ICU-Acquired Weakness.
Observational study in Critical care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Changes in rectus femoris diameter: a cooperation-independent assessment method for ICU-acquired weakness.Frontiers in nutrition · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate whether early measurement of quadriceps response to neuromuscular electrical stimulation (NMES) on mechanically ventilated patients could predict future ICU-acquired weakness (ICU-AW).
designProspective observational study.
settingLe Havre Hospital medico-surgical ICU. PATIENTS: All mechanically ventilated patients (> 24 hr), with no prospect of extubation in the following 24 hours.
interventionsNone. MEASUREMENTS AND MAIN
resultsEighty patients were enrolled in the study. Quadriceps response to NMES was measured using ultrasound and shear wave elastography (SWE) after 24 hours of mechanical ventilation, or on the day of neuromuscular blocker cessation if any (baseline). Stimulation intensity was adjusted to induce a quadriceps contraction causing knee extension (heel lifting). Changes in thickness (ultrasound) and stiffness (SWE) of the quadriceps during NMES were collected. An Medical Research Council sum score less than 48 within 24 hours of extubation diagnosed ICU-acquired weakness. A predictive model A, based on the quadriceps response to NMES at baseline, was compared with a model B, derived from identified risk factors, and a combined model (A + B). Of the 80 individuals, 39 (49%) developed ICU-AW. Time delay between intubation and baseline was 3.0 days, and between baseline and extubation was 7.5 days. Stimulation intensity at baseline showed an area under the curve (AUC) of 0.77, with a higher intensity required in individuals who developed ICU-AW (+21.6 mA; p < 0.001). Quadriceps thickness and stiffness during NMES at baseline were 3.83 ± 2.35 cm and 102.76 ± 74.1 kPa, respectively. Model A reached an AUC of 0.87 (95% CI, 0.79-0.95), which was not statistically different from model B. The combined model had the largest AUC (0.94; 95% CI, 0.89-0.99).
conclusionsA model based on the quadriceps response to NMES after 24 hours of mechanical ventilation, or on the day of neuromuscular blocker cessation seems promising to anticipate future ICU-AW.
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