Evidence map›Paper›PMID 41642405›Full record

ArticleJournal of gastrointestinal cancer2026

Association of the Number of Negative Lymph Nodes Removed with Overall Survival and Recurrence Rates in Patients with Colorectal Cancer Following Surgery: A Multicenter Retrospective Cohort Study.

Mansour Bahardoust, Fatemeh Naseri Rad, Mohammadsadra Shamohammadi, Roumina Behegam, Meisam Haghmoradi, Babak Godarzi, Adnan Tizmaghz

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mansour BahardoustDepartment of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fatemeh Naseri RadSchool of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mohammadsadra ShamohammadiGastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran. msadrashamohammadis@gmail.com.
Roumina BehegamSchool of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Meisam HaghmoradiDepartment of Orthopedic Surgery, Urmia University of Medical Sciences, Urmia, Iran.
Babak GodarziGastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.
Adnan TizmaghzFiroozabadi Clinical Research Development Unit (F A CRD U), Iran University of Medical Sciences (IUMS), Tehran, Iran. adnan_ti@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to evaluate the effect of the number of negative lymph nodes (NLNs) removed during surgery on overall survival (OS) and recurrence-free survival in patients with colorectal cancer following surgery.

methodsThis multicenter retrospective cohort study reviewed the medical profile of 1408 CRC patients who underwent surgery at one of our academic medical centers between 2012 and 2022. Based on the number of NLNs removed, patients were classified into three groups: 322 patients (< 7 NLNs), 668 (8–14 NLNs), and 418 patients (> 14 NLNs). The effect of the number of NLNs removed on OS and RFS rates was evaluated. Demographic characteristics, tumor characteristics, and pathological findings of the patients were obtained by reviewing their medical records.

resultsThe OS rate in patients with < 7, 8–14, and > 14 NLNs removed were 54.2%, 67.1%, and 79.2%, respectively (Log-rank = 64.2, P 0.001). The RFS rates in patients with < 7, 8–14, and > 14 NLNs removed were 49.3%, 60.4%, and 74.4%, respectively (Log-rank = 68.9, P 0.001). Cox multivariate analysis showed that the number of NLNs removed > 14 was significantly associated with improved OS (HR: 0.69, 95% CI: 0.51, 0.87; P: 0.001) and RFS (HR: 0.66, 95% CI: 0.50, 0.83; P: 0.001) rates in CRC patients. In addition, age ≥ 55 years, comorbidities, higher tumor stage (> II), depth of invasion (> T2), higher BMI, tumor location (rectum vs. colon), non-adjuvant therapy and poor tumor histology were significantly associated with reduced OS and RFS in CRC patients.

conclusionRemoving more NLNs during surgery can improve OS and RFS in patients with CRC. Paying attention to the number of NLNs removed during surgery can be a key factor in improving the prognosis of OS and RFS in CRC patients after surgery.

Indexed as

Colorectal NeoplasmsLymph Node ExcisionLymph NodesNeoplasm Recurrence, LocalAgedColorectal Surgical ProceduresFemaleHumansLymphatic MetastasisMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateColorectal cancerFive- survival rateNegative lymph nodesSurgery

Identifiers

PMID41642405

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.