Evidence map›Paper›PMID 41642413›Full record

ArticleInternational ophthalmology2026

Complications of minimally invasive surgery for primary open-angle glaucoma in patients with diabetic retinopathy: a retrospective cohort study.

Rishith Vaddavalli, Nada Madkour, Jessan A Jishu, Mohammad H Hussein, Ahmed A Abdelghany, Ahmed Abdelmaksoud, Manal S Fawzy, Eman A Toraih

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In one paragraph

Article in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Rishith VaddavalliTulane University School of Medicine, New Orleans, LA, 70112, USA.
Nada MadkourFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Jessan A JishuTulane University School of Medicine, New Orleans, LA, 70112, USA. jjishu@tulane.edu.ORCID http://orcid.org/0009-0008-3436-8889
Mohammad H HusseinOchsner Clinic Foundation, New Orleans, LA, 70112, USA.
Ahmed A AbdelghanyDepartment of Ophthalmology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Ahmed AbdelmaksoudDepartment of Internal Medicine, University of California, Riverside, 92521, USA.
Manal S FawzyCenter for Health Research, Northern Border University, 73213, Arar, Saudi Arabia.
Eman A ToraihDepartment of Surgery, Tulane University School of Medicine, New Orleans, LA, 70112, USA.ORCID http://orcid.org/0000-0001-9267-3787

Funding

Northern Border University NBU-CRP-2025-1442
6 · The paper itself

Abstract

objectiveMinimally invasive glaucoma surgery (MIGS) has become increasingly popular for treating primary open-angle glaucoma (POAG). However, data regarding complications for patients with comorbid diabetic retinopathy (DR) are limited. This study aimed to compare complications after MIGS in POAG patients with and without DR.

methodsThis is a retrospective cohort study using the TriNetX global health network. Adult patients with POAG who underwent MIGS were identified, with one group having comorbid DR and the other without. Propensity score matching was applied, yielding 518 patients per group for analysis. Complications assessed included vision loss, hypotony, ocular hypertension, cataract formation, eye infection, and any ocular hemorrhage. The primary outcomes were post-procedure complication rates and their statistical significance. Hazard ratios (HRs) with 95% confidence intervals (CIs) were computed.

resultsPatients with DR who underwent MIGS had a higher risk for vision loss (32.8% vs. 24.4%, HR 1.443, 95% CI 1.13-1.841) and ocular hemorrhage (13.4% vs. 4.3%, HR 3.194, 95% CI 1.929-5.288) compared to those without DR. Cataract formation rates were lower in DR patients at 3 months (44.4% vs. 50.6%, p = 0.046) and 6 months (53.3% vs. 59.5%, p = 0.048) post-surgery. No significant differences were observed in rates of hypotony, ocular hypertension, or eye infection.

conclusionMIGS in patients with DR is associated with an increased risk of post-procedure complications, particularly vision loss and ocular hemorrhage. These findings can aid in the clinical management and counseling of patients with both POAG and DR considering MIGS.

Indexed as

Diabetic RetinopathyGlaucoma, Open-AngleIntraocular PressureMinimally Invasive Surgical ProceduresPostoperative ComplicationsVisual AcuityAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesDiabetic retinopathyMinimally invasive glaucoma surgeryOcular hemorrhagePrimary open-angle glaucomaTriNetXVision loss

Identifiers

PMID41642413
PMCPMC12876447

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.