Evidence map›Paper›PMID 41642447›Full record

ReviewGeroScience2026

Histone modifications in biological age determination: mechanisms, biomarkers, and therapeutic perspectives.

Anjali Tripathi, Garima Sharma, Vinay Kumar Pandey, Sarvesh Rustagi, Ashish Ranjan Sharma, Meenakshi Jha, Abhijit Debnath, Jomon George Joy, Jin-Chul Kim, Abhimanyu Kumar Jha

Abstract readReview
PubMed Publisher
In one paragraph

Review in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anjali TripathiSchool of Health Sciences and Technology, UPES University Dehradun, Dehradun, India.
Garima SharmaInstitute of Forest Science, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Vinay Kumar PandeyResearch and Development Cell, Biotechnology Department, Manav Rachna International Institute of Research and Studies (Deemed to Be University) , Faridabad, Haryana, 121004, India.
Sarvesh RustagiDepartment of Food Technology, School of Agriculture, Maya Devi University, Dehradun, Uttarakhand, India.
Ashish Ranjan SharmaInstitute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-Si 24252 , Gangwon-Do, Republic of Korea.
Meenakshi JhaDepartment of Biotechnology, Amity University, Raipur, Chhattisgarh, India.
Abhijit DebnathNoida Institute of Engineering and Technology [Pharmacy Institute], 19 Knowledge Park-II, Greater Noida, Uttar Pradesh, India.
Jomon George JoyDepartment of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Jin-Chul KimDepartment of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea. jinkim@kangwon.ac.kr.ORCID http://orcid.org/0000-0003-3717-6096
Abhimanyu Kumar JhaDepartment of Biotechnology and Bioengineering, School of Biosciences and Technology, Galgotias University, Greater Noida, India. abhimanyu2006@gmail.com.

Funding

Ministry of Education RS-2018-NR031068Ministry of Education RS-2022-NR074969Ministry of Science and ICT, South Korea RS-2022-NR070087
6 · The paper itself

Abstract

Aging is the progressive decline in function at the cellular, tissue, and organismal levels that ultimately leads to mortality. The longevity of an organism is influenced by various internal and external factors, including nutrition, exercise, metabolic dysfunction, genomic instability, and epigenetic imbalance. Histone modifications, such as acetylation, methylation, phosphorylation, and ubiquitination, play a critical role in aging. These modifications illustrate histone changes crucial for regulating chromatin architecture and gene expression. The epigenetic clock signifies the impact of aging on our cells and is essential for accurately determining biological age. It demonstrates significant associations with histone modifications, underscoring their mechanistic importance in age-related changes. Histone alterations are closely associated with age-related diseases such as cancer, neurological disorders, and cardiovascular conditions. While the mechanistic function of histone modifications in biological aging is well-established, clinical application remains constrained. Emerging clinical studies targeting histone-modifying enzymes are beginning to investigate their potential as therapeutic options for age-related disorders. This review seeks to provide a comprehensive examination of histone modifications, including acetylation, methylation, and phosphorylation, as well as the impact of histone alterations on biological age, age-related diseases, and the importance of the epigenetic clock, with the aim of enhancing understanding of the epigenetic mechanisms associated with aging and facilitating the development of therapies to promote healthy aging. In this review, we also focus on the current status of such clinical trials and discuss future directions for translating these epigenetic insights into clinical applications.

Indexed as

Age-related diseasesChromatin remodellingEpigenetic clockHealthy agingHistone modification

Identifiers

PMID41642447

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.