Evidence map›Paper›PMID 41642455›Full record

ReviewCurrent oncology reports2026

Bevacizumab for the Management of Pediatric Radiation Necrosis: a Narrative Review.

Rimsha J Afzal, Zackary Tareky, Raquel Rudy, Steven P Howard, Nicholas Pytel, Brett Morris, Mustafa M Basree

Abstract readReview
In one paragraph

Review in Current oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rimsha J AfzalKentucky College of Osteopathic Medicine, Pikeville, KY, USA.
Zackary TarekyKentucky College of Osteopathic Medicine, Pikeville, KY, USA.
Raquel RudyHenry Ford Warren Hospital, Warren, MI, USA.
Steven P HowardDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Nicholas PytelDivision of Pediatric Hematology/Oncology and Bone Marrow Transplant, School of Medicine and Public Health, Madison, WI, USA.
Brett MorrisDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Mustafa M BasreeDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. mbasree@uwhealth.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewRadiation necrosis (RN) presents a significant challenge in the treatment of pediatric central nervous system tumors. This narrative review synthesizes current evidence on the use of bevacizumab (BEV) for managing pediatric RN, drawing from case reports, retrospective reviews, and prospective clinical trials. While high-quality prospective data remain limited, emerging evidence suggests that BEV may be effective in alleviating both clinical symptoms and radiographic manifestations of RN in pediatric patients. RECENT

findingsThis review explores the pathophysiology of RN, BEV’s mechanism of action, and existing evidence on the use of BEV in pediatric RN. Emerging evidence suggests that bevacizumab may provide symptomatic relief and radiographic improvement in pediatric patients with RN. By addressing current knowledge gaps, the aim is to provide insight into the potential role of BEV in improving outcomes for pediatric patients with RN.

Indexed as

Angiogenesis InhibitorsAntineoplastic Agents, ImmunologicalBevacizumabCentral Nervous System NeoplasmsNecrosisRadiation InjuriesChildHumansRadiotherapyAngiogenesis InhibitorsAntineoplastic Agents, ImmunologicalBevacizumabBevacizumabCentral nervous system tumorsPediatric radiation necrosisRadiation oncologyVascular endothelial growth factor (VEGF)

Identifiers

PMID41642455
PMCPMC12876104

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.