ReviewDevelopmental cell2026
Organizers in a dish: Modeling human CNS morphogenesis.
Review in Developmental cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human brain stands out for the scale of cellular and morphological complexity across anterior-posterior domains. Modeling the entire neuraxis is therefore essential to comprehend human neural development and disease. Brain organoids commonly recapitulate anterior regions due to the propensity of neural progenitors to acquire telencephalic identities and self-organize into cortical layers. In the embryo, posterior brain patterning is orchestrated by organizers, signaling centers positioned at anterior-posterior locations that are rarely induced in vitro. Several strategies have been developed to reproduce organizer signals, employing small molecules and recombinant morphogens, thereby expanding the in vitro repertoire of human neural identities. Despite this, posterior models do not yet reproduce the morphological complexity of their in vivo counterparts. In this review, we discuss how this discrepancy may stem from the inability to recapitulate the spatiotemporal dynamics of organizer activity and how recent technologies can balance guided differentiation and self-organization, enhancing the fidelity of human brain organoid models.
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Registered trials
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