Evidence mapPaperPMID 41644293Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2026

Network-Based Analysis for the Quantification of Brain and Body Immune Axes with Total-Body PET Imaging.

Lucia Maccioni, Agne Knyzeliene, Carlos J Alcaide-Corral, Victoria J M Reid, Timaeus E F Morgan, Martyn C Henry, Andrew Sutherland, Mattia Veronese, Adriana A S Tavares

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lucia MaccioniDepartment of Information Engineering, University of Padova, Padova, Italy.
Agne KnyzelieneInstitute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, United Kingdom.
Carlos J Alcaide-CorralInstitute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, United Kingdom.
Victoria J M ReidInstitute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, United Kingdom.
Timaeus E F MorganInstitute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, United Kingdom.
Martyn C HenrySchool of Chemistry, University of Glasgow, Glasgow, United Kingdom; and.
Andrew SutherlandSchool of Chemistry, University of Glasgow, Glasgow, United Kingdom; and.
Mattia VeroneseDepartment of Information Engineering, University of Padova, Padova, Italy.
Adriana A S TavaresInstitute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, United Kingdom; adriana.tavares@ed.ac.uk.

Funding

British Heart Foundation FS/19/34/34354British Heart Foundation RE/13/3/30183British Heart Foundation RG/16/10/32375Wellcome Trust 221295/Z/20/Z
6 · The paper itself

Abstract

The brain has long been viewed as an isolated immune-privileged organ. However, growing evidence suggests a critical role of the interplay between central and peripheral inflammation in pathologic conditions. This highlights the urgent need for novel system-level analysis approaches to study the complex brain-body cross-talk during immune responses. This study aims to validate network analysis of total-body 18-kDa translocator protein (TSPO) PET imaging for studying brain and body immune axes.

Indexed as

BrainImage Processing, Computer-AssistedPositron-Emission TomographyWhole Body ImagingAnimalsLipopolysaccharidesMaleMiceMice, Inbred C57BLReceptors, GABABzrp protein, mouseLipopolysaccharidesReceptors, GABAanimal imaginginflammationmolecular imagingPET

Identifiers

PMID41644293
PMCPMC13138107

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.