Evidence map›Paper›PMID 41644562›Full record

ArticleNature communications2026

MiRNAs shape mouse age-independent tissue adaptation to spaceflight via ECM and developmental pathways.

Friederike Grandke, Shusruto Rishik, Viktoria Wagner, Annika Engel, Nicole Ludwig, Kruti Calcuttawala, Fabian Kern, Verena Keller, Marcin Krawczyk, Louis Stodieck and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Friederike Grandke *Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.ORCID http://orcid.org/0000-0001-6185-1472
Shusruto Rishik *Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.
Viktoria WagnerClinical Bioinformatics, Saarland University, Saarbrücken, Germany.ORCID http://orcid.org/0000-0002-1957-0658
Annika EngelClinical Bioinformatics, Saarland University, Saarbrücken, Germany.ORCID http://orcid.org/0000-0001-5570-3115
Nicole LudwigDepartment of Human Genetics, Saarland University, Homburg, Germany.
Kruti CalcuttawalaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Fabian KernClinical Bioinformatics, Saarland University, Saarbrücken, Germany.ORCID http://orcid.org/0000-0002-8223-3750
Verena KellerClinical Bioinformatics, Saarland University, Saarbrücken, Germany.
Marcin KrawczykDepartment of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.
Louis StodieckBioServe Space Technologies, Aerospace Engineering Sciences, University of Colorado at Boulder, Boulder, CO, USA.
Virginia FergusonDepartment of Mechanical Engineering, University of Colorado at Boulder, Boulder, CO, USA.ORCID http://orcid.org/0000-0002-8448-4406
Amanda RobertsAnimal Models Core Facility, The Scripps Research Institute, La Jolla, CA, USA.
Eckart MeeseDepartment of Human Genetics, Saarland University, Homburg, Germany.
Nicholas SchaumDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Steven QuakeChan Zuckerberg Biohub, San Francisco, CA, USA.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5893-0831
Andreas KellerClinical Bioinformatics, Saarland University, Saarbrücken, Germany. andreas.keller@ccb.uni-saarland.de.ORCID http://orcid.org/0000-0002-5361-0895

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 469073465
6 · The paper itself

Abstract

As human space exploration accelerates, understanding the organism-wide molecular effects of longer spaceflight in mammals becomes increasingly critical. Non-coding RNAs like miRNAs are key to regulating this landscape. We thus analyze 686 small RNA samples of female mice from 13 solid organs at 3 and 8 months of age, after at least 3 weeks on the International Space Station and compare them to earth-bound controls. We observe significant spaceflight effects in systemic tissue remodeling pathways along the Fat-Liver-Pancreas axis and in heart, brain, spleen and thymus. The MIR-17/92 and MIR-1/133 families drive distinct molecular changes through specific gene targeting. Age-dependent changes, smaller in magnitude compared to age-independent changes, primarily involve tissue remodeling through MIR-8, MIR-154 and MIR-15 families in mesenteric adipose tissue, pancreas, and diaphragm. Our findings provide evidence on how spaceflight regulates mammalian gene expression in preparation for interplanetary spaceflight.

Indexed as

Adaptation, PhysiologicalExtracellular MatrixMicroRNAsSpace FlightAdipose TissueAgingAnimalsFemaleLiverMiceMice, Inbred C57BLPancreasThymus GlandMicroRNAs

Identifiers

PMID41644562
PMCPMC12876965

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.