ArticleNPJ digital medicine2026
Neck-to-knee dixon MRI thigh volume as a superior mass biomarker for Sarcopenia: evidence from the UK biobank.
Article in NPJ digital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Sarcopenia assessment requires biomarkers capturing muscle-specific strength beyond single-slice measurements. We developed an automated MRI framework segmenting 27 pelvic-thigh musculoskeletal structures to investigate muscle distribution as functional biomarkers. Among 37,004 UK Biobank participants (64.5 ± 7.9 years), transformer-based segmentation achieved Dice similarity coefficient of 0.896. Dixon MRI-derived thigh muscle volume showed exceptional DEXA concordance (r = 0.936). Posterior/anterior (P/A) muscle ratio independently predicted adverse outcomes: weak grip strength (OR 1.60, 95%CI 1.45-1.77), sarcopenia (OR 1.42, 95%CI 1.13-1.78), mortality (OR 1.49, 95%CI 1.23-1.81), and falls (OR 1.12, 95%CI 1.05-1.20), all p < 0.005, while left/right asymmetry showed no associations. Automated MRI phenotyping reveals muscle distribution patterns, particularly reduced anterior compartment volume, predict functional decline independent of total muscle mass, supporting evolution toward composition-aware sarcopenia criteria.
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