ArticleScientific reports2026
Resting-state fMRI reveals immediate hemodialysis-related changes in cognitive function and brain network connectivity in end-stage renal disease.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Multiplex functional connectome graph transformer for cognitive vulnerability in dialysis-treated chronic kidney disease.Frontiers in psychiatry · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
End-stage renal disease (ESRD) is associated with an increased risk. This study investigates associations between cognitive decline, resting-state networks (RSNs), and biochemical indicators in ESRD patients pre-/post-hemodialysis. 20 hemodialysis (HD) patients and 22 healthy controls underwent resting-state fMRI (rs-fMRI) and neuropsychological assessments. Resting-state networks (RSNs) were extracted via independent component analysis (ICA), with functional connectivity strength compared between pre-/post-HD patients and controls. Correlations between connectivity strength and biochemical indicators were analyzed. Compared to HCs, the post-HD group exhibited significantly decreased FC between the auditory-somatomotor network (t = - 5.120, P < 0.001) and the visual-somatomotor network (t = - 4.199, P < 0.001). In contrast, FC between the default mode and dorsal attention networks was significantly increased (t = 2.908, P = 0.006). While serum electrolytes and iron metabolism markers remained stable post-HD (all P > 0.05), phosphorus levels decreased (P = 0.046), with significant improvements in renal function: eGFR increased from 4.560 ± 1.650 to 16.980 ± 6.428 mL/min, urea, creatinine, and PTH levels decreased (all P < 0.001). Elevated baseline chloride levels were associated with reduced post-HD attention network connectivity (r = -0.758, P < 0.001), while cognitive improvement correlated inversely with baseline connectivity (r = -0.619, P = 0.004) and positively with connectivity plasticity (r = 0.513, P = 0.021). Immediate post-HD changes in resting-state network connectivity were associated with biochemical status and cognitive performance, suggesting potential neural substrates of cognitive dysfunction in ESRD.
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Registered trials
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