Evidence map›Paper›PMID 41644763›Full record

ArticleScientific reports2026

CD3

Thomas K Kilvaer, Dagny Førde, Erna-Elise Paulsen, Mona Irene Pedersen, Ana Paola Lombardi, Mehrdad Rakaee, Hallgeir Selven, Tom Donnem, Lill-Tove Rasmussen Busund, Sigve Andersen

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thomas K KilvaerDepartment of Oncology, University Hospital of North Norway, Tromso, Norway. kilvaer@gmail.com.
Dagny FørdeDepartment of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway.
Erna-Elise PaulsenDepartment of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway.
Mona Irene PedersenDepartment of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway.
Ana Paola LombardiDepartment of Medical Biology, UiT The Arctic University of Norway, Tromso, Norway.
Mehrdad RakaeeDepartment of Medical Biology, UiT The Arctic University of Norway, Tromso, Norway.
Hallgeir SelvenDepartment of Oncology, University Hospital of North Norway, Tromso, Norway.
Tom DonnemDepartment of Oncology, University Hospital of North Norway, Tromso, Norway.
Lill-Tove Rasmussen BusundDepartment of Medical Biology, UiT The Arctic University of Norway, Tromso, Norway.
Sigve AndersenDepartment of Oncology, University Hospital of North Norway, Tromso, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RUNX3, an important regulator of T-cell differentiation plays a crucial role in activation and maintenance of various T-cells including cytotoxic-, helper- and memory-cells. Former studies have highlighted RUNX3 as a prognostic factor across several cancer types, but few have studied its cell-type specific expression patterns. We used multiplex immunohistochemistry to assess and quantify cells co-expressing CD3 and RUNX3 in three cohorts consisting of 452 colon adenocarcinoma (COAD), 239 lung adenocarcinoma (LUAD) and 307 lung squamous cell carcinoma (LUSC) patients. Further, we correlated the expression of CD3/RUNX3 to disease-specific survival and to previously investigated immune markers in these cohorts. We found that a high density of CD3

Indexed as

Adenocarcinoma of LungCarcinoma, Squamous CellCD3 ComplexColonic NeoplasmsCore Binding Factor Alpha 3 SubunitLung NeoplasmsAgedBiomarkers, TumorFemaleHumansLymphocyte CountMaleMiddle AgedPrognosisBiomarkers, TumorCD3 ComplexCore Binding Factor Alpha 3 SubunitRunx3 protein, humanBiomarkerCD3Colon cancerCRCDigital pathologyLung cancerNSCLCRUNX3TNM-I

Identifiers

PMID41644763
PMCPMC12923705

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.