Evidence map›Paper›PMID 41644776›Full record

ArticleJournal of cardiovascular translational research2026

Transcription Factor SP1 Drives Myocardial Ischemia/reperfusion Injury By Transcription Activation-mediated GADD45G Upregulation.

Yaping Wang, Jianying Xue, Mingliang Cui, Fengjun Chang, Jiankuan Shi

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Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yaping WangDepartment of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
Jianying XueDepartment of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
Mingliang CuiDepartment of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
Fengjun ChangDepartment of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
Jiankuan ShiDepartment of Neurology, Xi'an International Medical Center Hospital, No. 777, Xitai Road, Xi'an, 710100, China. shijiankuan0308@163.com.ORCID 0009-0004-5303-6039

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial ischemia-reperfusion injury (MIRI) is an unresolved clinically fatal complication in the management of acute myocardial infarction (AMI). Growth arrest and DNA damage-inducible gene 45 Gamma (GADD45G) plays a vital role in the regulation of MIRI. However, the underlying mechanisms remain unclear. GADD45G and SP1 expression were upregulated in hypoxia/reoxygenation (H/R)-treated H9C2 cells. H/R treatment repressed H9C2 cell viability, and induced apoptosis, oxidative stress, and inflammatory response. Moreover, GADD45G deficiency could relieve H/R-triggered H9C2 cell injury. In mechanism, SP1 was a transcription factor of GADD45G and activated the transcription of GADD45G via binding to its promoter region. Besides, SP1 knockdown alleviated MI/R-induced pathological damage in the myocardial tissue of rats by regulating GADD45G. In conclusion, SP1 could promote H/R-induced cardiomyocyte injury and MI/R-caused rat myocardial tissue pathological injury by increasing GADD45G, providing a promising therapeutic target for MIRI treatment.

Indexed as

Antigens, DifferentiationIntracellular Signaling Peptides and ProteinsMyocardial InfarctionMyocardial Reperfusion InjuryMyocytes, CardiacSp1 Transcription FactorTranscriptional ActivationAnimalsApoptosisCell LineDisease Models, AnimalGADD45 ProteinsHumansMaleOxidative StressPromoter Regions, GeneticAntigens, DifferentiationGADD45 ProteinsIntracellular Signaling Peptides and ProteinsSp1 Transcription FactorGADD45GH9C2 cardiomyocytesInflammatory responseMyocardial ischemia–reperfusion injuryOxidative stressSP1

Identifiers

PMID41644776

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.