Evidence map›Paper›PMID 41644796›Full record

ArticleNature microbiology2026

Host factors dictate gut microbiome alterations in chronic kidney disease more strongly than kidney function.

H Krukowski, S Valkenburg, A Vich Vila, L F Maciel, J F Vázquez-Castellanos, T Gryp, M Joossens, W Van Biesen, F Verbeke, M Derrien and 3 more

Abstract read
In one paragraph

Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Gut microbes · 2026
    Trial
  3. Article
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  6. Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

H Krukowski *Laboratory of Molecular Bacteriology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-0368-7250
S Valkenburg *Nephrology Unit, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium.ORCID http://orcid.org/0000-0003-3019-550X
A Vich VilaLaboratory of Molecular Bacteriology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
L F MacielLaboratory of Molecular Bacteriology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
J F Vázquez-CastellanosLaboratory of Molecular Bacteriology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
T GrypNephrology Unit, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium.
M JoossensLaboratory of Microbiology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0001-8410-5528
W Van BiesenNephrology Unit, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium.
F VerbekeNephrology Unit, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium.ORCID http://orcid.org/0000-0003-2112-6326
M DerrienLaboratory of Molecular Bacteriology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-8841-9153
G R B HuysLaboratory of Molecular Bacteriology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-7092-4837
G GlorieuxNephrology Unit, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium.ORCID http://orcid.org/0000-0002-7641-4707
J RaesLaboratory of Molecular Bacteriology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium. Jeroen.raes@kuleuven.be.ORCID http://orcid.org/0000-0002-1337-041X

Funding

EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 101149152EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 860329Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G017815N
6 · The paper itself

Abstract

Despite recent progress, microbial associations reported in chronic kidney disease (CKD) remain inconsistent. Here we combined quantitative faecal metagenomics (n = 130) and cross-study biomarker comparisons (n

Indexed as

Gastrointestinal MicrobiomeKidneyRenal Insufficiency, ChronicBacteriaBiomarkersDisease ProgressionDysbiosisFecesFemaleGlomerular Filtration RateHumansMaleMetagenomicsBiomarkers

Identifiers

PMID41644796
PMCPMC12962972

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.