ArticleJournal of perinatology : official journal of the California Perinatal Association2026
Variable clinical and hemodynamic effect of sildenafil in extreme premature infants with bronchopulmonary dysplasia-associated pulmonary hypertension.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Tailoring Therapy to Bronchopulmonary Dysplasia Phenotype: A Ten-Year Experience in Precision Medicine.Children (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore the clinical and hemodynamic effects of sildenafil in extreme premature population with bronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH). STUDY
designSingle-centre retrospective study on infants born <28 weeks with BPD-PH on sildenafil. The respiratory severity score was assessed at four time points (72 h-4wks). Echocardiographic data were compared before and after sildenafil.
resultsSixty-four infants were included. The mean gestational age was 26.1 ± 1.6 weeks. 30(47%) infants showed improvement in RSS, 17(26%) had no change and 17(26%) showed poor RSS. 15(88) in the poor RSS group had an early onset PH. The improved RSS group reduced tricuspid regurgitation (3.3 ± 0.6 to 2.7 ± 0.5 m/s, p = 0.007). The pulmonary acceleration time (PAAT), PAAT/RVET (right ventricular ejection time), and RV fractional area change showed improvement in all groups. The poor RSS group had high pretreatment systolic blood pressure (90.7 ± 8.8 vs 82.7 ± 4.4 mmHg, p = 0.04).
conclusionVariable clinical response to sildenafil warrants close monitoring of respiratory status.
Identifiers
41644806What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.