ArticleBiological trace element research2026
Antidepressant-Related Signaling Pathways of Zinc Oxide Nanoparticles in a Mouse Model of Postpartum Depression.
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Postpartum depression (PPD) constitutes a serious mental health concern linked to behavioral disturbances. Zinc exerts a significant influence on mood states. This novel study revealed the antidepressant-like action of zinc oxide nanoparticles (ZnO NPs) and their underlying mechanisms in the PPD model through the forced swimming test (FST), emphasizing their therapeutic potential for maternal mental health. PPD was induced in female mice via intraperitoneal injection of progesterone (5 mg/kg) for 5 days, followed by 3 days withdrawal period. The depressed mice received ZnO NPs (5, 10, and 20 mg/kg) 30 min before the FST. Moreover, L-arginine (NO precursor, 750 mg/kg), L-NAME (non-specific NOS inhibitor, 10 mg/kg), WAY100635 (selective 5-HT
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