ArticleBMC medicine2026
Genetic risk factors modulate the association between physical activity and colorectal cancer.
Abstract read
In one paragraph
Article in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Update of
Authors and funding
74 authors.
Anita R Peoples *Huntsman Cancer Institute, Salt Lake City, UT, USA.
Mireia Obón-Santacana *Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, 08908, Spain.
Andre E KimDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Eric S KawaguchiDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yubo FuDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Conghui QuPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Ferran Moratalla-NavarroUnit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, 08908, Spain.
John MorrisonDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yi LinPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Stephanie A BienPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
D Timothy BishopLeeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Emmanouil BourasDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Daniel D BuchananColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Peter T CampbellDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
David V ContiDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Douglas Ac CorleyDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Matthew A DevallCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Niki DimouNutrition and Metabolism Branch, International Agency for Research On Cancer, World Health Organization, Lyon, France.
David A DrewDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Stephen B GruberDepartment of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.
Marc J GunterNutrition and Metabolism Branch, International Agency for Research On Cancer, World Health Organization, Lyon, France.
Sophia HarlidDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
Tabitha A HarrisonPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Jeroen R HuyghePublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Temitope O KekuCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Anshul KundajeDepartment of Genetics, Stanford University, Stanford, CA, USA.
Juan Pablo LewingerDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Li LiDepartment of Family Medicine, University of Virginia, Charlottesville, VA, USA.
Brigid M LynchCancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Vicente MartínConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, 28029, Spain.
Neil MurphyNutrition and Metabolism Branch, International Agency for Research On Cancer, World Health Organization, Lyon, France.
Christina C NewtonDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
Shuji OginoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sheetal HardikarHuntsman Cancer Institute, Salt Lake City, UT, USA.
Jennifer OseHuntsman Cancer Institute, Salt Lake City, UT, USA.
Rish K PaiDepartment of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Julie R PalmerSlone Epidemiology Center at Boston University, Boston, MA, USA.
Nikos PapadimitriouNutrition and Metabolism Branch, International Agency for Research On Cancer, World Health Organization, Lyon, France.
Bens PardameanBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
Andrew J PellattDepartment of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mila PinchevDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Elizabeth A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Gad RennertTechnion-Israel Institute of Technology and APRPM, Haifa, Israel.
Edward A Ruiz-NarvaezDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Lori C SakodaPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Robert E SchoenDepartments of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Anna ShcherbinaDepartment of Genetics, Stanford University, Stanford, CA, USA.
Mariana C SternDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yu-Ru SuBiostatistics Division, Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Claire E ThomasPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Yu TianDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Konstantinos K TsilidisDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
Caroline Y UmDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
Franzel J B van DuijnhovenDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
Bethany Van GuelpenDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jun WangDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Michael O WoodsDivision of Biomedical Sciences, Memorial University of Newfoundland, St. John's, Canada.
Anna H WuDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Cornelia M Ulrich *Huntsman Cancer Institute, Salt Lake City, UT, USA. neli.ulrich@hci.utah.edu.
Ulrike Peters *Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. upeters@fredhutch.org.
W James Gauderman *Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. jimg@usc.edu.
Victor Moreno *Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, 08908, Spain. v.moreno@iconcologia.net.
Funding
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI JOHN Alan SHEPHERD · 1996 to 2026
$56.2MStatistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KIMBERLY D SIEGMUND · 2016 to 2026
$25.5MUsing Functional Genomics to Inform Gene Environment Interactions for Colorectal CancerR01CA201407 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GAUDERMAN, WILLIAM JAMES, LE MARCHAND, LOIC · 2016 to 2020
$9.6MCeramides as novel drivers of metabolic dysfunction and colorectal cancerU01CA272529 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Mary Christine Playdon, SCOTT A SUMMERS · 2022 to 2026
$4.7MInterdisciplinary Epidemiologic Consortium to Investigate T-cell Response in Colorectal CancerR01CA248857 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI OGINO, SHUJI, PETERS, ULRIKE · 2020 to 2025
$3.6MAn integrative omics approach to investigate gene-environment interaction in colorectal cancer riskR01CA273198 · NCI · FRED HUTCHINSON CANCER CENTER · PI William JAMES GAUDERMAN, ULRIKE PETERS · 2023 to 2026
$3.5MCreatine supplementation and resistance training to preserve muscle mass and attenuate cancer progression: A double-blind randomized controlled trialR01CA281759 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Neeraj Agarwal, Adriana Coletta · 2023 to 2026
$2.7MUsing Functional Data to Reveal Gene-Environment Interaction in Colorectal CancerR21CA191312 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HSU, LI · 2015 to 2016
$421kNCI NIH HHS P01 CA196569NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA201407NCI NIH HHS R01 CA248857NCI NIH HHS R01 CA273198NCI NIH HHS R01 CA281759NCI NIH HHS R21 CA191312NCI NIH HHS U01 CA137088, R01 CA059045, U01 CA164930, R01 CA201407, R01 CA244588NCI NIH HHS U01 CA272529
Abstract
backgroundPhysical activity is an established protective factor for colorectal cancer (CRC), but it is unclear if genetic variants modify this effect. To investigate this possibility, we conducted a genome-wide gene-physical activity interaction analysis.
methodsUsing logistic regression (1-d.f), two-step screening and testing method (EDGE), and joint tests (3-d.f), we analyzed interactions between common genetic variants across the genome and physical activity in relation to CRC risk. Self-reported physical activity levels were categorized as active (≥ 8.75 MET-h/wk) vs. inactive (< 8.75 MET-h/wk; 39,992 participants) and as study- and sex-specific quartiles of activity (42,602 participants).
resultsPhysical activity was inversely associated with CRC risk overall (OR [active vs. inactive] = 0.85; 95% CI = 0.81-0.90). The two-step EDGE method identified an interaction between rs4779584, an intergenic variant near the GREM1 and SCG5 genes, and physical activity for CRC risk (p-interaction = 2.6 × 10
conclusionsIn summary, we identified two genetic variants that modified the association between physical activity and CRC risk. One of them, related to GREM1 and SCG5, suggests that the bone morphogenetic protein (BMP)-related, inflammatory, and/or insulin signaling pathways may be involved in the protective association between physical activity and colorectal carcinogenesis.
Indexed as
Colorectal NeoplasmsExerciseGenetic Predisposition to DiseaseAgedFemaleGenome-Wide Association StudyHumansIntercellular Signaling Peptides and ProteinsMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsGREM1 protein, humanIntercellular Signaling Peptides and ProteinsColorectal cancerGene-environment interactionGWASPhysical activity
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.