Evidence map›Paper›PMID 41645227›Full record

ArticleAlzheimer's research & therapy2026

Real-world diagnostic performance of blood-based biomarkers for Alzheimer's disease: robust performance except after stroke and high charlson comorbidity index.

Sinthujah Vigneswaran, Inge M W Verberk, Rebecca Z Rousset, Mariam Gouda, Calvin Trieu, Thomas Claessen, Elsmarieke van de Giessen, Afina W Lemstra, David Wilson, Yolande A L Pijnenburg and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sinthujah VigneswaranNeurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, De Boelelaan 1118 1081 HZ Amsterdam, Amsterdam, The Netherlands. s.vigneswaran@amsterdamumc.nl.
Inge M W VerberkNeurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, De Boelelaan 1118 1081 HZ Amsterdam, Amsterdam, The Netherlands.
Rebecca Z RoussetNeurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, De Boelelaan 1118 1081 HZ Amsterdam, Amsterdam, The Netherlands.
Mariam GoudaNeurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, De Boelelaan 1118 1081 HZ Amsterdam, Amsterdam, The Netherlands.
Calvin TrieuNeurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, De Boelelaan 1118 1081 HZ Amsterdam, Amsterdam, The Netherlands.
Thomas ClaessenNeurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, De Boelelaan 1118 1081 HZ Amsterdam, Amsterdam, The Netherlands.
Elsmarieke van de GiessenDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, De Boelelaan 1118 1081 HZ Amsterdam, Amsterdam, The Netherlands.
Afina W LemstraAlzheimer Center, Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, De Boelelaan 1118 1081 HZ Amsterdam, Amsterdam, The Netherlands.
David WilsonQuanterix corporation, 900 Middlesex Turnpike Billerica 01821, Massachusetts, USA.
Yolande A L PijnenburgAlzheimer Center, Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, De Boelelaan 1118 1081 HZ Amsterdam, Amsterdam, The Netherlands.
Wiesje M van der FlierAlzheimer Center, Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, De Boelelaan 1118 1081 HZ Amsterdam, Amsterdam, The Netherlands.
Charlotte E TeunissenNeurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, De Boelelaan 1118 1081 HZ Amsterdam, Amsterdam, The Netherlands.
Argonde C van HartenAlzheimer Center, Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, De Boelelaan 1118 1081 HZ Amsterdam, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate plasma biomarker interpretation is essential for diagnosing Alzheimer's disease (AD). This study evaluated how patient factors influence the association between plasma biomarkers and amyloid status in a memory clinic population.

methodsA cross-sectional study of 1199 participants from the Amsterdam Dementia Cohort analysed plasma biomarkers (pTau217, pTau181, Aβ

resultsStroke, hypercholesterolemia, antidepressant use and Charlson Comorbidity Index (CCI) influenced biomarker performance. Stroke reduced the diagnostic value of pTau217, Aβ

conclusionsOverall, patient factors had limited impact on biomarkers, but caution is needed for patients with stroke or high CCI.

Indexed as

Alzheimer DiseaseStrokeAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersCohort StudiesComorbidityCross-Sectional StudiesFemaleGlial Fibrillary Acidic ProteinHumansMaleMiddle AgedPeptide FragmentsPositron-Emission TomographyAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)BiomarkersGlial Fibrillary Acidic ProteinPeptide Fragmentstau ProteinsAlzheimer’s diseaseBlood-based biomarkersClinical implementationComorbidities

Identifiers

PMID41645227
PMCPMC12977799

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.