Evidence mapPaperPMID 41645281Full record

SynthesisBrain and behavior2026

Association of the Stress Hyperglycemia Ratio and Prognosis After Endovascular Treatment: A Systematic Review and Meta-Analysis.

Jiayu You, Qianshuo Liu, Xingqiang Li

Abstract readSystematic ReviewMeta-AnalysisReview
In one paragraph

Synthesis in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jiayu YouDepartment of Neurology and Neuroscience, Shenyang Brain Institute, Shenyang First People's Hospital, Shenyang, Liaoning, China.
Qianshuo LiuDepartment of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Xingqiang LiDepartment of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeStress hyperglycemia (SH) is prevalent in patients with acute ischemic stroke (AIS). The stress hyperglycemia ratio (SHR), calculated as the fasting blood glucose (FBG)/glycosylated hemoglobin (HbA1c) ratio, has been widely used to evaluate SH. However, the correlation between SHR and clinical outcomes in AIS patients with large vessel occlusion (LVO) following endovascular treatment (EVT, including mechanical thrombectomy, contact aspiration, intra-arterial thrombolysis, excluding intravenous thrombolysis) remains unclear. This study aimed to perform a meta-analysis to investigate the association between SHR and clinical outcomes in EVT-treated AIS patients with LVO.

methodsA comprehensive literature search was conducted across multiple databases, including PubMed, Web of Science, Embase, and the Cochrane Library, to identify studies investigating the association between SHR and clinical outcomes. The entire study was executed in strict adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. References were screened based on pre-specified inclusion and exclusion criteria, and the Newcastle-Ottawa Scale (NOS) was rigorously applied to assess potential bias risks in the selected studies. RevMan 5.3 software was utilized for performing meta-analyses on the included literature.

resultsA total of 10 studies met the inclusion criteria, and 3646 AIS patients who underwent EVT were included in this analysis. The meta-analysis results demonstrated a higher SHR was associated with an increased risk of poor outcomes (modified Rankin Scale [mRS] 3-6) at 90 days (odds ratio [OR] = 2.65, 95% CI: 2.30-3.06, p < 0.001), mortality (OR = 2.62, 95% CI: 1.81-3.79, p < 0.001), intracranial hemorrhage (ICH) (OR = 1.53, 95% confidence interval [CI]: 1.27-1.85, p < 0.001), symptomatic intracranial hemorrhage (sICH) (OR = 2.05, 95% CI: 1.27-3.30, p < 0.003) after EVT.

conclusionA higher SHR may increase the occurrence of poor outcomes, mortality, ICH, and sICH in AIS patients caused by LVO after EVT. SHR is associated with poor prognosis in AIS patients caused by LVO after EVT.

Indexed as

Blood GlucoseEndovascular ProceduresHyperglycemiaIschemic StrokeHumansPrognosisBlood Glucoseclinical outcomeendovascular treatmentmeta‐analysisstress hyperglycemia ratiostroke

Identifiers

PMID41645281
PMCPMC12876047

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.