Evidence map›Paper›PMID 41645294›Full record

ArticleEnvironmental microbiome2026

Effects of developmental stage-driven fungal community shifts on biomass and metabolite accumulation in Gastrodia elata.

Zhao-Yu Zhang, Guang-Fei Wei, Li-Ying Hou, Guo-Zhuang Zhang, Xiao-Dong Li, Ming Li, Lin Meng, Guo-Ying Wu, Jia Xu, Yu-Xin Zhou and 2 more

Abstract read
In one paragraph

Article in Environmental microbiome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhao-Yu Zhang *Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193, China.
Guang-Fei Wei *Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 10700, China.
Li-Ying HouInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 10700, China.
Guo-Zhuang ZhangInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 10700, China.
Xiao-Dong LiLueyang County Traditional Chinese Medicine Industry Development Service Center, Hanzhong, 724300, China.
Ming LiLueyang County Traditional Chinese Medicine Industry Development Service Center, Hanzhong, 724300, China.
Lin MengLueyang County Traditional Chinese Medicine Industry Development Service Center, Hanzhong, 724300, China.
Guo-Ying WuLueyang County Traditional Chinese Medicine Industry Development Service Center, Hanzhong, 724300, China.
Jia XuInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 10700, China.
Yu-Xin ZhouInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Chao SunInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193, China. csun@implad.ac.cn.
Lin-Lin DongInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 10700, China. lldong@icmm.ac.cn.

Funding

grants from the Scientific and technological innovation project of China Academy of Chinese Medical Science CI2023E001TS03-04-01Nuclear Technology R&D Program HJSYF2024(31)Shaanxi Province Key R&D Plan 2024SF-ZDCYL-03-10
6 · The paper itself

Abstract

backgroundFungal communities play crucial roles in plant development and metabolite accumulation, especially in fully mycoheterotrophic medicinal plants like Gastrodia elata. While the importance of fungal symbiosis in G. elata is recognized, how fungal community dynamics evolve across its entire growth cycle and how they influence biomass and bioactive compound accumulation remain largely unclear.

resultsHigh-throughput sequencing combined with multi-omics analyses revealed that developmental progression significantly shapes fungal diversity and composition, thereby influencing biomass and metabolite accumulation in G. elata. These effects are mediated by stage-specific selective recruitment and dynamic remodeling of fungal communities in both rhizome and rhizosphere compartments. Structural equation modeling indicated that developmental stage, fungal α-diversity, and community structure exert both direct and indirect effects on biomass and the accumulation of bioactive compounds. High-resolution association network analyses further identified key functional fungal groups, particularly wood and soil saprotrophs, as major contributors to seed stem biomass regulation. Notably, the symbiotic fungus Armillaria showed the strongest positive correlation with gastrodin accumulation, while wood saprotrophs and plant pathogens also significantly influenced its levels.

conclusionsThis study systematically elucidates the dynamic changes in fungal communities across different developmental stages of G. elata and their effects on biomass and bioactive metabolite accumulation. Our findings highlight the central role of microbe-plant-metabolite interactions in regulating biomass and bioactive metabolite production, offering valuable insight for optimizing the cultivation and quality of medicinal plants through microbiome-targeted strategies.

Indexed as

BiomassFungal community dynamicsGastrodia elataMetabolite accumulationMycoheterotrophy

Identifiers

PMID41645294
PMCPMC12973763

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.