Evidence map›Paper›PMID 41645336›Full record

ArticleJournal of animal science and biotechnology2026

Genomic analysis reveals convergent signatures of selection for milk traits in sheep and goats.

Zhanerke Akhatayeva, Yilong Shi, Kairat Dossybayev, Nurlan Malmakov, Hairong Cheng, Narantuya Baatar, Ji Yang, Menghua Li, Kejian Lin, Songsong Xu

Abstract read
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Article in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zhanerke AkhatayevaInstitute of Grassland Research, Chinese Academy of Agricultural Sciences, Hohhot, 010010, China.
Yilong ShiCollege of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Kairat DossybayevLPP "Kazakh Research Institute for Livestock and Fodder Production", Almaty, 050035, Kazakhstan.
Nurlan MalmakovLPP "Kazakh Research Institute for Livestock and Fodder Production", Almaty, 050035, Kazakhstan.
Hairong ChengOrdos Agricultural and Pastoral Technology Promotion Center, Ordos, Inner Mongolia Autonomous Region, 017200, China.
Narantuya BaatarResearch Institute of Animal Husbandry, Ulaanbaatar, 17029, Mongolia.
Ji YangCollege of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Menghua LiCollege of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Kejian LinInstitute of Grassland Research, Chinese Academy of Agricultural Sciences, Hohhot, 010010, China. linkejian@caas.cn.
Songsong XuCollege of Animal Science and Technology, China Agricultural University, Beijing, 100193, China. xusongsong@cau.edu.cn.

Funding

National Key Research and Development Program of China 2022YFE0113300Project of Northern Agriculture and Livestock Husbandry Technology Innovation Center, Chinese Academy of Agricultural Sciences BFGJ2022002
6 · The paper itself

Abstract

backgroundConvergent evolution offers a unique lens through which to explore the molecular underpinnings of significant phenotypic transformations. Similar selective pressures likely drove the evolution of analogous milk traits in sheep and goats. Consequently, the current study aimed to identify common selection signals for milk traits across dairy and non-dairy breeds of sheep and goats worldwide.

resultsIn this study, a total of 308 whole-genome sequences from diverse sheep (n = 108) and goat (n = 200) breeds, including both dairy and non-dairy types, across the world were utilized. The population structure and genetic diversity of dairy and non-dairy sheep and goat breeds were characterized. Species-specific genes associated with milk traits, such as POU2F1, ABCD2, TRNAC-GCA in sheep and PRPF6, VPS13C, TPD52L2, NFX1 and B4GALT1 in goats, were identified. Further gene annotation and bioinformatics analyses indicated that different biological pathways are important for milk traits in each species: fatty acid oxidation and AMP metabolic process in sheep, the U2-type spliceosomal complex and propanoate metabolism in goats. Additionally, common signatures of selection such as CLASP1, PDS5B, ZNF831, CCDC73 were found in sheep and goats. Haplotype and transcriptional analyses further confirmed the role of these genes in milk production and provided evidence for their analogous evolution in sheep and goats. The CLASP1 gene was identified as a target of convergent selection, representing a promising candidate for genetic improvement programs in dairy species.

conclusionsThese results provide insights into the genetic basis of convergent dairy traits, offering valuable targets for improving milk production and advancing dairy sheep and goat breeding programs.

Indexed as

BreedingConvergent evolutionGoatMilk traitsSheep

Identifiers

PMID41645336
PMCPMC12879437

What Socratic holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.