Evidence map›Paper›PMID 41645533›Full record

ArticleHuman gene therapy2026

Prenatal Intraportal Delivery of Polymeric Nanoparticles to Fetal Rhesus Monkeys (

Alexandra S Piotrowski-Daspit, Anna Y Lynn, David A Eaton, Laura G Bracaglia, Arianna I Markey, Ryland D Mortlock, David H Stitelman, Michele L Martinez, Charles C Lee, Harvey J Kliman and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human gene therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexandra S Piotrowski-DaspitDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Anna Y LynnDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
David A EatonDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
Laura G BracagliaDepartment of Chemical & Biological Engineering, Villanova University, Villanova, Pennsylvania, USA.
Arianna I MarkeyDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Ryland D MortlockDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
David H StitelmanDepartment of Surgery, Yale University, New Haven, Connecticut, USA.
Michele L MartinezDepartment of Pediatrics, University of California, Davis, California, USA.
Charles C LeeCalifornia National Primate Research Center, University of California, Davis, California, USA.
Harvey J KlimanDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University, New Haven, Connecticut, USA.
Peter M GlazerDepartment of Therapeutic Radiology, Yale University, New Haven, Connecticut, USA.
Alice F TarantalDepartment of Pediatrics, University of California, Davis, California, USA.
W Mark SaltzmanDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Medical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5M
SCGE Comparative Studies SupplementU42OD027094 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HARTIGAN-O'CONNOR, DENNIS J., SEGAL, DAVID J · 2019 to 2023
$14.2M
Poly(amine-co-ester)s for targeted delivery of gene editing agents to treat cystic fibrosis in animal models: SCGE Disease Models Studies SupplementUH3HL147352 · NHLBI · YALE UNIVERSITY · PI GLAZER, PETER M, SALTZMAN, W. MARK · 2021 to 2022
$2.4M
Targeted correction of the human CFTR geneR01HL125892 · NHLBI · YALE UNIVERSITY · PI EGAN, MARIE E, GLAZER, PETER M · 2015 to 2018
$2.2M
PNA Nanoparticles for Gene Editing In VivoU01AI145965 · NIAID · YALE UNIVERSITY · PI GLAZER, PETER M, LY, DANITH H · 2019 to 2022
$1.6M
Developing Gene Editing Therapeutics, Biodegradable Polymeric Delivery Vehicles, and High-throughput Platforms for the Treatment of Cystic Fibrosis- SupplementR00HL151806 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PIOTROWSKI-DASPIT, ALEXANDRA SARAH ANNUKKA · 2023 to 2025
$856k
Nonhuman Primate IVIS Spectrum Imaging SystemS10OD018102 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TARANTAL, ALICE F · 2014 to 2014
$405k
Ultrasound Imaging for Nonhuman Primate Translational ResearchS10OD016261 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TARANTAL, ALICE F · 2013 to 2013
$203k
Optimization of Polymeric Nanoparticles Encapsulating Peptide Nucleic Acids for In Utero Gene Editing of the Fetal Brain.F30HD106692 · NICHD · YALE UNIVERSITY · PI LYNN, ANNA Y · 2021 to 2023
$115k
NHLBI NIH HHS R00 HL151806NHLBI NIH HHS R01 HL125892NHLBI NIH HHS UH3 HL147352NIAID NIH HHS U01 AI145965NICHD NIH HHS F30 HD106692NIGMS NIH HHS T32 GM136651NIH HHS P51 OD011107NIH HHS S10 OD016261NIH HHS S10 OD018102NIH HHS U42 OD027094
6 · The paper itself

Abstract

Preliminary investigations focused on biodistribution of polymeric nanoparticles (NPs) shortly after ultrasound-guided delivery via the portal vein in early second-trimester fetal rhesus monkeys. Results demonstrated that poly(lactic-co-glycolic acid) (PLGA) NPs (

Indexed as

FetusNanoparticlesPolymersAnimalsFemaleGene Transfer TechniquesGreen Fluorescent ProteinsLactic AcidLiverMacaca mulattaPolyethylene GlycolsPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerPortal VeinPregnancyTissue DistributionGreen Fluorescent ProteinsLactic AcidPolyethylene GlycolsPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerPolymersbiodistributionfetal rhesus macaqueintraportal deliverynanoparticles

Identifiers

PMID41645533
PMCPMC12978997

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.