ArticleImmunity, inflammation and disease2026
NLRP3-Caspase-1 Axis in Human Adipose Tissue Crown-Like Structures: A Potential Mediator of Inflammation and the Effects of Bariatric Surgery.
Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- NLRP3 Inhibitor KBD3536 Attenuates Acute Inflammation, Radiation-Induced Skin Injury, and Early Metabolic Dysfunction in Preclinical Models.Pharmaceuticals (Basel, Switzerland) · 2026Article
- NLRP3-Caspase-1 Axis in Human Adipose Tissue Crown-Like Structures: A Potential Mediator of Inflammation and the Effects of Bariatric Surgery.Immunity, inflammation and disease · 2026Article
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6 authors.
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Abstract
backgroundObesity-related comorbidities, such as type 2 diabetes, are associated with chronic inflammation mediated by macrophages. This inflammation is characterized by the accumulation of macrophages in crown-like structures (CLS) surrounding dead adipocytes within adipose tissue. In a recent study, we reported a significant reduction in CLS-associated macrophages following bariatric surgery. The NLRP3 inflammasome and its downstream effector, Caspase-1, are well-established mediators of metabolic dysfunction and inflammation in obesity.
methodsImmunohistochemical single- and multiplex staining of subcutaneous adipose tissue (SAT) samples from patients with obesity was performed to characterize the detailed distribution of NLRP3 and Caspase-1. The samples were collected during gastric bypass surgery and at a 1-year follow-up.
resultsBoth NLRP3 and Caspase-1 were expressed by CD68-positive macrophages in SAT including both single macrophages and those forming CLS. A reduction in the total number of SAT macrophages expressing these proteins was detected following gastric bypass. Furthermore, NLRP3 and Caspse-1 were observed in the endothelium of vascular structures.
conclusionsOur findings demonstrate that both CLS-forming and single cell macrophage populations in human adipose tissue express NLRP3 and Caspase-1. The study highlights the significance of the NLRP3 inflammasome macrophages in the pathogenesis of adipose tissue inflammation in obesity. The previously reported abundance of CLS in untreated obesity and their reduction after bariatric surgery suggest that the NLRP3-Caspase-1 axis within CLS may serve as an important mediator of the beneficial metabolic effects associated with bariatric surgery.
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