Evidence map›Paper›PMID 41645896›Full record

ArticleHypertension (Dallas, Tex. : 1979)2026

SIRT1-NCOR2 Corepressor Modulates Trophoblast-Macrophage Interactions in Preeclampsia.

Zhenzhen Liu, Xiaoyue Zhang, Chengjie Wang, Shouling Luo, Haiyan Liu, Yi Yu, Jiangnan Pei, Yao Tang, Weirong Gu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhenzhen LiuDepartment of Obstetrics and Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China (Z.L., X.Z., C.W., S.L., H.L., Y.Y., J.P., Y.T., W.G.).
Xiaoyue ZhangDepartment of Obstetrics and Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China (Z.L., X.Z., C.W., S.L., H.L., Y.Y., J.P., Y.T., W.G.).
Chengjie WangDepartment of Obstetrics and Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China (Z.L., X.Z., C.W., S.L., H.L., Y.Y., J.P., Y.T., W.G.).ORCID 0009-0000-8074-9633
Shouling LuoDepartment of Obstetrics and Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China (Z.L., X.Z., C.W., S.L., H.L., Y.Y., J.P., Y.T., W.G.).
Haiyan LiuDepartment of Obstetrics and Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China (Z.L., X.Z., C.W., S.L., H.L., Y.Y., J.P., Y.T., W.G.).ORCID 0000-0002-3812-7520
Yi YuDepartment of Obstetrics and Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China (Z.L., X.Z., C.W., S.L., H.L., Y.Y., J.P., Y.T., W.G.).
Jiangnan PeiDepartment of Obstetrics and Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China (Z.L., X.Z., C.W., S.L., H.L., Y.Y., J.P., Y.T., W.G.).
Yao TangDepartment of Obstetrics and Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China (Z.L., X.Z., C.W., S.L., H.L., Y.Y., J.P., Y.T., W.G.).ORCID 0000-0001-8305-7632
Weirong GuDepartment of Obstetrics and Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China (Z.L., X.Z., C.W., S.L., H.L., Y.Y., J.P., Y.T., W.G.).ORCID 0000-0002-2157-0454

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreeclampsia is a severe hypertensive disorder of pregnancy associated with low

methodsWe conducted coculture experiments to analyze trophoblast RARRES2 and macrophage CMKLR1 interactions, performed luciferase and chromatin immunoprecipitation assays to validate transcription factors for RARRES2 in trophoblasts, and utilized mass spectrometry and immunoprecipitation to identify transcriptional coregulators. cKO (trophoblast-specific

resultsLow-SIRT1 expression in trophoblasts promoted M1-type macrophage polarization and inhibited trophoblast invasion, mediated by the RARRES2-CMKLR1 interaction. SIRT1 regulated RARRES2 expression in trophoblasts by recruiting NCOR2 (nuclear receptor corepressor 2). cKO mice showed preeclampsia-like symptoms and RARRES2-CMKLR1 activation at the maternal-fetal interface, which were reversed by

conclusionsThis study highlights SIRT1's potential role in regulating abnormal trophoblast-macrophage interactions at the maternal-fetal interface in preeclampsia and offers a new strategy for its early prediction and prevention.

Indexed as

MacrophagesNuclear Receptor Co-Repressor 2Pre-EclampsiaSirtuin 1TrophoblastsAnimalsCells, CulturedCoculture TechniquesDisease Models, AnimalFemaleHumansMiceMice, KnockoutPregnancyNcor2 protein, mouseNuclear Receptor Co-Repressor 2Sirt1 protein, mouseSirtuin 1macrophagesplacentapreeclampsiaprogesteronetrophoblasts

Identifiers

PMID41645896
PMCPMC13189378

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.