ArticleCirculation2026
TRPM7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn
Xin Li, Xiaohan Li, Cindy Xintong Li, Jianlin Feng, Zhichao Yue, Jiajie Yan, Masayuki Matsushita, Yibing Qyang, Loren W Runnels, Xun Ai and 1 more
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In one paragraphArticle in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Xin LiPat and Jim Calhoun Cardiology Center (Xin Li, Xiaohan Li, C.X.L., J.F., Z.Y., L.Y.), University of Connecticut School of Medicine, Farmington.ORCID 0009-0009-1205-1976 Xiaohan LiPat and Jim Calhoun Cardiology Center (Xin Li, Xiaohan Li, C.X.L., J.F., Z.Y., L.Y.), University of Connecticut School of Medicine, Farmington.
Cindy Xintong LiPat and Jim Calhoun Cardiology Center (Xin Li, Xiaohan Li, C.X.L., J.F., Z.Y., L.Y.), University of Connecticut School of Medicine, Farmington.ORCID 0009-0006-8836-6737 Jianlin FengPat and Jim Calhoun Cardiology Center (Xin Li, Xiaohan Li, C.X.L., J.F., Z.Y., L.Y.), University of Connecticut School of Medicine, Farmington.
Zhichao YuePat and Jim Calhoun Cardiology Center (Xin Li, Xiaohan Li, C.X.L., J.F., Z.Y., L.Y.), University of Connecticut School of Medicine, Farmington.
Jiajie YanDepartment of Physiology and Cell Biology, College of Medicine/Wexner Medical Center, The Ohio State University, Columbus (J.Y., X.A.).
Masayuki MatsushitaDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.).
Yibing QyangYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT (Xin Li, Y.Q.).ORCID 0000-0002-0332-2449 Loren W RunnelsDepartment of Pharmacology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ (L.W.R.).ORCID 0000-0002-2537-7360 Xun AiDepartment of Physiology and Cell Biology, College of Medicine/Wexner Medical Center, The Ohio State University, Columbus (J.Y., X.A.).ORCID 0000-0003-0739-0286 Lixia YuePat and Jim Calhoun Cardiology Center (Xin Li, Xiaohan Li, C.X.L., J.F., Z.Y., L.Y.), University of Connecticut School of Medicine, Farmington.ORCID 0000-0002-3558-091X Funding
Atrial and blood JNK in Postoperative AFR01HL168728 · OHIO STATE UNIVERSITY · 2025 to 2025
$685kCalcium Signaling Mechanisms in Cardiac FibrogenesisR01HL171486 · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · 2025 to 2025
$664kThe JNK2-NLRP3 nexus in atrial fibrillation and its anti-AF therapeutic potentialsR01AA031056 · OHIO STATE UNIVERSITY · 2025 to 2025
$584kTransient Receptor Potential Melastatin 2 (TRPM2) in Ischemic StrokeR01NS131661 · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · 2025 to 2025
$407kNHLBI NIH HHS R01 HL146744NHLBI NIH HHS R01 HL147350NHLBI NIH HHS R01 HL168728NHLBI NIH HHS R01 HL171486NIAAA NIH HHS R01 AA031056NINDS NIH HHS R01 NS131661
6 · The paper itselfAbstract
backgroundIschemic heart disease is one of the leading causes of death worldwide. Timely reperfusion is necessary for myocardium salvage but triggers paradoxical cardiomyocyte death and contributes to up to 50% of the final infarct size, known as lethal ischemia/reperfusion (I/R) injury. TRPM7 (transient receptor potential melastatin 7) is a divalent cation-permeable, nonselective channel kinase that can sense oxidative stress and release Zn
methodsTRPM7 expression was determined in hearts from patients with ischemic heart failure and I/R-injured mice. Global (
resultsWe found that TRPM7 was significantly upregulated in myocardium from both patients with ischemic heart failure and I/R-injured mice. Global TRPM7 deficiency markedly reduced infarct size and improved cardiac function after I/R injury. Using
conclusionsTRPM7-mediated intracellular Zn
Indexed as
HomeostasisMyocardial Reperfusion InjuryMyocytes, CardiacProtein Serine-Threonine KinasesTRPM Cation ChannelsZincAnimalsFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutProtein Serine-Threonine KinasesTRPM7 protein, humanTrpm7 protein, mouseTRPM Cation ChannelsZinccardiomyocytehiPSCischemia-reperfusion injurypyroptosisTRPM7Zn2+ homeostasis
Identifiers
PMID41645903
PMCPMC13019533
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