Evidence mapPaperPMID 41646296Full record

ArticleResearch square2026

Partial Freezing Enables Functional Preservation of Kidney Grafts for up to 10 Days.

Korkut Uygun, McLean Taggart, Madeeha Hassan, Arnaud Lyon, O Sila Ozgur, Christopher Taveras, Mohammadreza Mojoudi, Thomas Agius, Sophie Van Tulder, Christina Zheng and 6 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Korkut UygunMassachusetts General Hospital, Harvard Medical School.ORCID 0000-0003-2088-7860
McLean TaggartMassachusetts General Hospital - Harvard Medical School.ORCID 0000-0003-3889-3513
Madeeha HassanMassachusetts General Hospital, Harvard Medical School.
Arnaud LyonMassachusetts General Hospital & Harvard Medical School.ORCID 0000-0003-1781-330X
O Sila OzgurMassachusetts General Hospital, Harvard Medical School.
Christopher TaverasMassachusetts General Hospital, Harvard Medical School.
Mohammadreza MojoudiMassachusetts General Hospital, Harvard Medical School.ORCID 0009-0009-8743-1164
Thomas AgiusETH Zurich.ORCID 0000-0001-6917-0831
Sophie Van TulderMassachusetts General Hospital - Harvard Medical School.ORCID 0009-0004-2536-3382
Christina ZhengPrinceton University.
Michael MacarthurPrinceton University.ORCID 0000-0003-3593-6995
Heidi Yeh
Shannon TessierMassachusetts General Hospital - Harvard Medical School.ORCID 0000-0003-2373-232X
Mehmet TonerMassachusetts General Hospital, Harvard Medical School.ORCID 0000-0002-3647-3665
Alban LongchampMassachusetts General Hospital, Harvard Medical School.ORCID 0000-0002-1743-4935

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · 1991 to 2025
$10.1M
High subzero preservation of liver for transplantationR01DK114506 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · 2023 to 2025
$1.6M
P&F programP30DK135043 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$1.1M
A quantitative viability metric for liver transplantation using Resonance Raman SpectroscopyR01DK134590 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · 2023 to 2025
$962k
Cryopreservation of zebrafish larvae and embryos for biomedical researchR24OD034189 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$642k
Genetic-engineered control of the immunogeneic state of vascular composite allografts during preservationR01EB028782 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$627k
High subzero heart preservation: from zebrafish to mammalsR01HL157803 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$420k
NHLBI NIH HHS R01 HL157803NIBIB NIH HHS R01 EB028782NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK135043NIDDK NIH HHS R01 DK096075NIDDK NIH HHS R01 DK114506NIDDK NIH HHS R01 DK134590NIH HHS R24 OD034189
6 · The paper itself

Abstract

Kidney transplantation is critically limited by the shortage of available donor organs, exacerbated by the discarding of viable organs due to insufficient allocation time. Here, we demonstrate the application of nature-inspired partial freezing for long-term storage of kidney grafts. We show that, after 10 days of storage, partially frozen swine and human kidneys retain improved function compared to those preserved using traditional static cold storage, as assessed via simulated transplantation.

Identifiers

PMID41646296
PMCPMC12869680

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.