ArticleResearch square2026
Acute effects of nitrous oxide on visual processing: a connectome study in healthy adults.
Niloufar Pouyan, Chelsea M Kaplan, Tony E Larkin, Eric Ichesco, Maximillian K Eagan, Katrin H Preller, Jeffrey B Dunworth, Richard E Harris, George A Mashour, Steven E Harte
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Niloufar PouyanDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0003-4606-3528 Chelsea M KaplanDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Tony E LarkinDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-7470-7039 Eric IchescoDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Maximillian K EaganDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Katrin H PrellerPharmaco-Neuroimaging and Cognitive-Emotional Processing, Department of Adult Psychiatry and Psychotherapy, Psychiatric University Clinic Zurich and University of Zurich, Zurich, Switzerland.
Jeffrey B DunworthDepartment of Mathematics, University of Michigan, Ann Arbor, MI, USA.
Richard E HarrisDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
George A MashourDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Steven E HarteDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Funding
Role of the Prefrontal Cortex in the Control of Arousal StatesR01GM111293 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER, PAL, DINESH · 2015 to 2022
$2.6MUniversity of Michigan Anesthesiology Post-Doctoral Research Training ProgramT32GM103730 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Chad M Brummett, SACHIN KHETERPAL · 2014 to 2026
$1.9MNIGMS NIH HHS R01 GM111293NIGMS NIH HHS T32 GM103730
6 · The paper itselfAbstract
Introduction: Nitrous oxide (N Methods: Thirteen healthy adults completed a placebo-controlled, crossover fMRI study acquired before and during subanesthetic N Results: gPPI analyses revealed that increased unpleasantness under N Discussion: These findings suggest that visual processing under N
Indexed as
anterior insulaHierarchical clusteringNetwork modularityNitrous oxidePsychedelic stateVisual processing
Identifiers
PMID41646355
PMCPMC12869621
What Socratic holds
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