Evidence map›Paper›PMID 41646368›Full record

ArticleResearch square2026

GWAS of Active Music Engagement Frequency in the Canadian Longitudinal Study on Aging.

Tara Henechowicz, Brooke Wolford, Rachana Nitin, Yasmina Mekki, Alyssa Scartozzi, Peyton Coleman, Earvin Tio, Grace Schlicht, Srishti Nayak, Michael Thaut and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tara HenechowiczUniversity of Toronto.ORCID 0000-0001-6680-2098
Brooke WolfordORCID 0000-0003-3153-1552
Rachana Nitin
Yasmina Mekki
Alyssa Scartozzi
Peyton Coleman
Earvin TioCentre for Addiction and Mental Health.ORCID 0000-0002-0521-779X
Grace Schlicht
Srishti Nayak
Michael Thaut
Daniel FelskyCentre for Addiction and Mental Health.ORCID 0000-0003-1831-9848
Reyna Gordon

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Neurobiological Markers of Rhythm: Risk and Resilience for Language AcquisitionR01DC016977 · NIDCD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORDON, REYNA LEIGH · 2019 to 2023
$3.5M
Biomarkers of Rhythmic Communication: Integrating Foundational and Translational ApproachesDP2HD098859 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORDON, REYNA LEIGH · 2018 to 2018
$2.4M
NCATS NIH HHS UL1 TR000445NICHD NIH HHS DP2 HD098859NIDCD NIH HHS R01 DC016977
6 · The paper itself

Abstract

Active music engagement (AME), i.e., playing a musical instrument or singing, is moderately heritable and may support resilience to age-related functional decline. To understand AME's genetic architecture, we conducted a genome-wide association study (GWAS) in the Canadian Longitudinal Study on Aging (n = 23,782 with genetically inferred European ancestry). SNP-based heritability was estimated at 10%, revealing 21 independent loci at suggestive significance (

Indexed as

agingCLSAcognitiongenetic correlationsGWASlanguageMendelian Randomizationmental healthmotor functionmusicmusicalitymusic engagementpartitioned heritabilitypsychiatric disorder risk

Identifiers

PMID41646368
PMCPMC12869635

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.