ArticleFrontiers in medicine2025
Sex- and country-specific associations of hyperuricemia and inflammation with vascular aging across populations with diverse cardiovascular risks.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Introduction: The importance of measuring vascular age has been emphasized in numerous studies, highlighting its critical role in precision medicine. This cross-sectional heterogeneity exploration study examined sex- and country-specific association of serum uric acid (SUA) and inflammation, measured as high sensitivity C-reactive protein (hs-CRP), and vascular aging across populations with diverse cardiovascular risks. Methods: This work analyzed data from three cohorts: 4,802 individuals from Sweden (SCAPIS - The Swedish CArdioPulmonary bioImage Study, Results: The study involved individuals with a mean age of 56 (±8) years, 53% women, 48% never smokers, 41% with hypertension, and 20% with diabetes. In adjusted for cardiometabolic factors linear models, hs-CRP was associated with cfPWV only in Swedish men ( Conclusion: This cross-sectional exploratory study provides evidence that SUA and hs-CRP are associated with vascular aging, although their predictive value should be interpreted in a sex- and country-specific context.
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