ArticleESMO real world data and digital oncology2024
Real-world survival of patients treated with taxane therapy after exposure to immunotherapy and platinum-based chemotherapy for advanced non-small-cell lung cancer without actionable mutations.
Article in ESMO real world data and digital oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Docetaxel in Non-Small Cell Lung Cancer: A Multi-Centre Real-World Evidence Analysis in the Immunotherapy Era.Current oncology (Toronto, Ont.) · 2026Article
- Next-generation immunotherapy: igniting new hope for lung cancer.Therapeutic advances in medical oncology · 2024Review
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5 authors.
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Abstract
Background: The current therapy for advanced non-small-cell lung cancer (NSCLC) often incorporates frontline use of programmed death (ligand) 1 [PD-(L)1] inhibitors concomitantly or sequentially with platinum-based chemotherapy. For patients whose cancer then progresses, the impact of prior immunotherapy on the efficacy of subsequent chemotherapy remains unclear. This retrospective study aimed to evaluate survival with taxane-containing regimens after prior chemotherapy and immunotherapy. Methods: Using a US nationwide, longitudinal deidentified database, we selected patients ≥18 years old with unresectable stage IIIB-IV NSCLC, without actionable mutations, who had ECOG performance status of 0-1 when initiating a taxane-containing regimen from 4 March 2015 to 31 May 2021 after prior PD-(L)1 inhibitor and platinum-based chemotherapy, concomitantly or sequentially. Overall survival (OS) was estimated using the Kaplan-Meier method. The data cut-off was 31 May 2022. Results: Of 587 eligible patients [median age, 68 years, 316 (54%) male, 560 (95%) with nonsquamous NSCLC], 528 (90%) had received one to two prior lines of therapy before taxane monotherapy (195 patients; 33%) or combination therapy (392; 67%). The median patient follow-up to death or data cut-off was 9.2 months (range <0.1-71.8 months). The median OS from taxane initiation was 9.0 months [95% confidence interval (CI) 8.1-9.6 months] and OS rates were 39% and 16% at 12 and 24 months, respectively. The median OS was similar with taxane monotherapy (9.0 months; 95% CI 8.1-11.2 months) and taxane combination therapy (8.8 months; 95% CI 7.5-9.6 months). Conclusions: Survival with taxane-containing regimens after prior chemotherapy and immunotherapy is consistent with historical outcomes that predate immunotherapy. These findings highlight the need for more effective subsequent treatments after prior PD-(L)1 inhibitor and platinum-based chemotherapy for patients with advanced NSCLC without actionable mutations.
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