Evidence map›Paper›PMID 41647421›Full record

ArticleRSC advances2026

Targeting cell cycle and apoptotic pathways with newly synthesized diselenide-linked imidazolone analogues with strong CDK6-targeting potential.

Marwa Abdel-Motaal, Saad Shaaban, Samia S Hawas, Asma M Elsharif, Marwa Sharaky, Fatema S Alatawi, Mohamed E Eissa, Arwa Omar Al Khatib, Hany M Abd El-Lateef, Medhat Asem and 1 more

Abstract read
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In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marwa Abdel-MotaalDepartment of Chemistry, College of Science, Qassim University Buraidah 51452 Qassim Saudi Arabia.
Saad ShaabanDepartment of Chemistry, College of Science, King Faisal University Al-Ahsa 31982 Saudi Arabia sibrahim@kfu.edu.sa.ORCID https://orcid.org/0000-0002-7835-6926
Samia S HawasDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt akarmalawy@horus.edu.eg.
Asma M ElsharifDepartment of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University Dammam 31441 Saudi Arabia.
Marwa SharakyCancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University Cairo Egypt.
Fatema S AlatawiDepartment of Biochemistry, Faculty of Science, University of Tabuk Tabuk Saudi Arabia.
Mohamed E EissaDepartment of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh 11623 Saudi Arabia.
Arwa Omar Al KhatibFaculty of Pharmacy, Al-Ahliyya Amman University Amman Jordan.
Hany M Abd El-LateefDepartment of Chemistry, College of Science, King Faisal University Al-Ahsa 31982 Saudi Arabia sibrahim@kfu.edu.sa.
Medhat AsemDepartment of Civil Engineering, College of Engineering and Information Technology, Onaizah Colleges Qassim 56447 Saudi Arabia.
Ahmed A Al-KarmalawyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt akarmalawy@horus.edu.eg.ORCID https://orcid.org/0000-0002-8173-6073

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel panel of diselenide-linked imidazolone derivatives was synthesized and biologically profiled, revealing a promising new chemotype with broad-spectrum anticancer activity. Among the series, compounds 6b, 6d, and 6g demonstrated exceptional growth-inhibitory (GI) potency, achieving GI% values of 80.32%, 79.24%, and 86.40%, respectively-substantially outperforming doxorubicin (61.49%). Notably, 6g emerged as the lead candidate, exhibiting robust cytotoxicity across diverse cancer models with IC

Identifiers

PMID41647421
PMCPMC12871525

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.