Evidence map›Paper›PMID 41647439›Full record

ArticleMaterials & design2026

Novel stable "sandwich" cyclodextrin inclusion of a lipophilic S-nitrosothiol for controlled delivery of nitric oxide.

Xinyao Wang, Partha S Sheet, Kaikai Wang, Hannah J Naldrett, Orsolya Lautner-Csorba, Steven P Schwendeman, Gergely Lautner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials & design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinyao WangDepartment of Biomedical Engineering, University of Michigan, 2800 Plymouth Rd., Ann Arbor, MI, 48109, USA.
Partha S SheetDepartment of Pharmaceutical Sciences, University of Michigan, 2800 Plymouth Rd., Ann Arbor, MI, 48109, USA.
Kaikai WangDepartment of Pharmaceutical Sciences, University of Michigan, 2800 Plymouth Rd., Ann Arbor, MI, 48109, USA.
Hannah J NaldrettDepartment of Pharmaceutical Sciences, University of Michigan, 2800 Plymouth Rd., Ann Arbor, MI, 48109, USA.
Orsolya Lautner-CsorbaDepartment of Surgery, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.
Steven P SchwendemanDepartment of Biomedical Engineering, University of Michigan, 2800 Plymouth Rd., Ann Arbor, MI, 48109, USA.
Gergely LautnerDepartment of Pharmaceutical Sciences, University of Michigan, 2800 Plymouth Rd., Ann Arbor, MI, 48109, USA.

Funding

Electrochemically Generated Inhaled Nitric Oxide (iNO) delivery via High Flow Nasal Cannula (HFNC)R01HL168099 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gergely Lautner · 2023 to 2026
$2.2M
Controlled Photochemical Release of Nitric Oxide for Biomedical ApplicationsR01EB028775 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHWENDEMAN, STEVEN P. · 2020 to 2023
$1.8M
NHLBI NIH HHS R01 HL168099NIBIB NIH HHS R01 EB028775
6 · The paper itself

Abstract

Nitric oxide (NO) is a versatile biological signaling molecule with applications in antimicrobial, anticancer, and cardiovascular therapies. A newly developed NO donor, S-nitroso-1-adamantane thiol (SNAT), has previously demonstrated excellent antithrombogenic and antimicrobial properties when impregnated into PVC tubing of extracorporeal circuits. However, the hydrophobicity of SNAT and its storage stability remain a major challenge for further biomedical applications. Here, we report a novel NO delivery system based on the inclusion of the highly lipophilic SNAT within hydroxypropyl-β-cyclodextrin (CD), forming a stable "sandwich" cyclodextrin inclusion complex (CD-SNAT). Spectroscopic, structural, and morphological characterization confirmed successful SNAT inclusion in the CD cavity. The CD-SNAT complex showed excellent aqueous solubility, and remarkable aqueous stability at physiological pH, even resistant to trace amounts of transition metal ions, which are detrimental to common S-nitrosothiols, like S-nitroso-N-acetyl-penicillamine. NO release could be efficiently triggered by endogenous free thiols like cysteine, or UV light. Sustained and cysteine-induced NO release from CD-SNAT was confirmed by chemiluminescence. Intracellular NO delivery from SNAT was visualized in melanoma cells in the presence of cysteine. Remarkably, the solid complex remained >90% intact after six-month storage at room temperature. Hence, CD-SNAT provides a stable, tunable, biocompatible platform for controlled NO delivery, with promising biomedical applications.

Indexed as

Controlled releaseCyclodextrinHost-guest chemistryNitric oxideS-nitroso-1-adamantane thiol

Identifiers

PMID41647439
PMCPMC12872045

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.