ArticleAvicenna journal of phytomedicine2026
Combination therapy with bone marrow-derived mesenchymal stem cell transplantation and propolis improves streptozotocin-induced kidney injury in diabetic rats.
Article in Avicenna journal of phytomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The aim of the current study was to determine the therapeutic effects of combination therapy with propolis extract and rat bone marrow mesenchymal stem cells (MSCs) in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Firstly, characterization of MSCs was performed and MTT assay was done to determine the optimum concentration of propolis for incubation with MSCs. Rats were divided into 8 groups: Control, diabetic , diabetic+propolis, diabetic+metformin, diabetic+MSCs, diabetic+MSCs+ propolis, diabetic+ MSCs pre-incubated with propolis. MSCs were transplanted via the tail vein on the 7 Results: Serum glucose concentration in all propolis and MSCs treatment groups was significantly lower than that of the STZ group on the 21 Conclusion: Our findings demonstrated, MSCs, propolis, and their combination demonstrate positive effects on renal function, kidney index, and histopathology in all treated animals compared with the STZ diabetic rats. These beneficial effects are comparable to those of metformin.
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