Evidence map›Paper›PMID 41647560›Full record

ArticleFundamental research2026

Disruption of the nucleocapsid-RNA condensation by punicalagin is a broad-spectrum antiviral approach.

Shao-Zhen Jiang, Liu-Bing Yu, Beilei Shen, Jie Pan, Xiao-Wei Li, Rong-Bo Luo, Ling-Jun Fan, Bing-Shuo Qian, Yunkai Zhu, Ziqiao Wang and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Shao-Zhen JiangKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Liu-Bing YuKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Beilei ShenChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Jie PanNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China.
Xiao-Wei LiNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China.
Rong-Bo LuoChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Ling-Jun FanChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Bing-Shuo QianChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Yunkai ZhuKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Ziqiao WangKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Yu LiuNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China.
Tingting LiNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China.
Xin-Ran ZhangNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China.
Yu YuNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China.
Wen XueNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China.
Tian XiaNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China.
Hong CaiNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China.
Qiu-Ying HanNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China.
Kai WangNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China.
Xin XuNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China.
Rong ZhangKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Xue-Min ZhangKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Ai-Ling LiKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Tao ZhouKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Yuwei GaoChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Ming ZhaoKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Tao LiKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The formation of liquid condensates by nucleocapsid (N) protein and viral RNA is a critical and highly conserved event in the life cycle of numerous viruses. Targeting this process emerges as a possible strategy to combat viral infections. Here, we discover that punicalagin, a natural compound derived from Punica granatum, exhibits potent pan-antiviral activity. Through a screening of 2799 compounds, we identified that punicalagin inhibits the formation of N-RNA condensations at nanomolar concentrations, resulting in significant inhibition of viral replication. The oral administration of punicalagin effectively dampens the viral load in tissues of mice infected with various viruses, such as SARS-CoV-2, vesicular stomatitis virus (VSV) and influenza A virus (IAV). Moreover, we show that punicalagin also blocks the virus-stimulated inflammation by targeting mitochondrial antiviral signaling protein (MAVS), thereby alleviating tissue damage and lethality in the infected animals. Thus, by reporting that punicalagin targets the conserved process across different viruses, our work suggests a new paradigm for developing antiviral therapies against both current and future viral threats.

Indexed as

Broad-spectrum antiviral activityInflammation responseInfluenza A virusLiquid condensatesNucleocapsidPunicalaginSARS-CoV-2

Identifiers

PMID41647560
PMCPMC12869781

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.