ArticleHorticulture research2026
AP2/ERF transcription factors regulate the biosynthesis of terpenoids, phenolics, and alkaloids in plants.
Article in Horticulture research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Overview of molecular mechanisms underlying stress responses; signaling pathways and secondary metabolite synthesis in plants.Plant molecular biology · 2026Review
- Integrated transcriptomic and metabolomic analyses reveal sodium selenite-induced molecular responses and metabolic remodeling in Stemona tuberosa roots.Protoplasma · 2026Article
- A Novel AP2/ERF Transcription Factor Controls Trichome Initiation and Fruit Development in Cucumber.Plant biotechnology journal · 2026Article
- AaSnRK2.6 interacts with AaORA to positively regulate artemisinin biosynthesis inHorticulture research · 2026Article
- The Convergence of Biotechnological Strategies in Medicinal Plants: From Individual Approaches Toward an Integrated Systems Framework.International journal of molecular sciences · 2026Review
- Article
- Seed-specific overexpression of DREB2G alters seed morphology, oil accumulation, and germination in Arabidopsis.Plant cell reports · 2026Article
- The TaERF3-Plants (Basel, Switzerland) · 2026Article
- Tomato NAC2-DREB2 module fine-tunes saline-alkali stress sensitivity via modulation of melatonin biosynthesis and ROS homeostasis.Horticulture research · 2026Article
- A review of flavonoids at the crossroads of plant defense: integrating biotic and abiotic stress tolerance through AI- and CRISPR/Cas-guided metabolic reprogramming.Frontiers in plant science · 2026Review
- Responses and adaptations of plants to abiotic stress: transcriptional regulation of secondary metabolic pathways, metabolomics, and nanobiological approaches.Frontiers in genetics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AP2/ERF transcription factors (TFs) constitute a large, plant-specific family that acts as a central hub integrating developmental and environmental signals to modulate the biosynthesis of secondary metabolites. These compounds, including terpenoids, phenolic compounds, and alkaloids, are vital for plant survival and are of immense value to human health and industry. This review provides a comprehensive synthesis of the molecular mechanisms by which AP2/ERF TFs regulate these crucial metabolic pathways. We systematically classify and dissect their regulatory modes, including direct binding to cis-elements (e.g. GCC-box, CE1, and DRE/CRT), indirect control via upstream signaling cascades, co-regulation through physical interactions with other TF families (e.g. MYB, bHLH, WRKY), and feedback regulation. We present numerous case studies across diverse plant species, highlighting both conserved principles and species-specific adaptations in the control of high-value natural products like artemisinin, tanshinones, anthocyanins, and nicotine. Furthermore, we discuss the emerging roles of AP2/ERF TFs in metabolic engineering and synthetic biology, and outline future research directions, emphasizing the application of multi-omics and CRISPR/Cas9 technologies to unravel and engineer these complex regulatory networks for targeted overproduction of valuable phytochemicals.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.