ArticleFrontiers in public health2026
Exploring the nonlinear association between serum uric acid and the TG/HDL-C Ratio: insights from school-aged children with adenoid or tonsillar hypertrophy.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Serum uric acid (SUA) plays a critical role in metabolic dysfunction, including insulin resistance (IR) and lipid dysregulation. This study investigates the association between SUA and the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio in school-aged children with adenoid or tonsillar hypertrophy. Methods: A single-center retrospective study of 3,026 school-aged children with adenoid or tonsillar hypertrophy was conducted. Baseline characteristics, metabolic markers, and the TG/HDL-C ratio were analyzed across SUA quartiles. Spearman's test was used to explore the associations between clinical parameters and the TG/HDL-C ratio. A restricted cubic splines (RCS) linear regression model was used to explore the nonlinear relationships between SUA and the TG/HDL-C ratio. Results: SUA levels were positively associated with the TG/HDL-C ratio ( Conclusion: Our study identified a nonlinear relationship between SUA levels and the TG/HDL-C ratio in school-age children with adenoid or tonsillar hypertrophy. This nonlinear pattern persisted in sex-stratified analyses, with males exhibiting a higher SUA inflection point compared to females. These findings suggest that SUA could serve as a practical marker for early metabolic risk assessment.
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