SynthesisFrontiers in psychiatry2025
Adverse childhood experiences and subsequent impact on adulthood cognitive impairment: a systematic review and meta-analysis.
Synthesis in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
2 authors.
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Abstract
Background: Cognitive impairment is a significant threat to adult quality of life. Adverse childhood experiences (ACEs) may have prolonged effects on cognitive impairment in adulthood. This systematic review and meta-analysis aimed to investigate the association between ACEs and adult-onset cognitive impairment. Methods: We systematically searched databases, including PubMed, Embase, Web of Science, and the Cochrane Library, from inception through February 16, 2025. Two independent investigators conducted literature screening, data extraction, and quality assessment using the Newcastle-Ottawa Scale. Meta-analysis was performed applying RevMan5.4.1. Results: Four studies- two cross-sectional studies, one cohort study, and one case-control study-were included. Meta-analysis results indicated that the Childhood Trauma Questionnaire (CTQ) total score (mean difference [MD]= 7.06, 95% confidence interval [CI] [0.87,13.24], Conclusion: Adverse childhood experiences may be associated with an increased risk of cognitive impairment, but a causal relationship could not be established owing to limited observational evidence. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420250655749, identifier CRD420250655749.
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