Evidence map›Paper›PMID 41648114›Full record

ArticlebioRxiv : the preprint server for biology2026

Programmed Double-stranded RNA Formation Enables Meiotic Stage Transitions.

Hao Wu, Xinan Liu, Yihan Xiong, Yun Bai, Kevin M Weeks

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hao WuSchool of Life Science and Technology, ShanghaiTech University, 201210 Shanghai, China.ORCID 0009-0000-4981-1179
Xinan LiuSchool of Life Science and Technology, ShanghaiTech University, 201210 Shanghai, China.
Yihan XiongSchool of Life Science and Technology, ShanghaiTech University, 201210 Shanghai, China.
Yun BaiSchool of Life Science and Technology, ShanghaiTech University, 201210 Shanghai, China.ORCID 0000-0002-5441-9777
Kevin M WeeksDepartment of Chemistry, University of North Carolina, Chapel Hill, NC 27599-3290, USA.ORCID 0000-0002-6748-9985

Funding

Discovery and Function of Higher-Order RNA StructureR35GM122532 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kevin M Weeks · 2017 to 2026
$5.7M
NIGMS NIH HHS R35 GM122532
6 · The paper itself

Abstract

Cell fate transitions rely on extensive transcriptional activation mediated by transcription factors, yet the equally important processes that ensure the selective removal of pre-existing mRNAs remain elusive. We uncover widespread formation of double-stranded RNA (dsRNA) during earlyto-middle meiosis using quantitative RNA structure analysis, and validate hundreds of natural antisense transcripts (NATs) through long-read sequencing. These NATs are induced by meiosis-specific transcription factors, including Ndt80p, and pair with sense mRNAs to drive cytoplasmic aggregation of the resulting dsRNAs. These dsRNA aggregates are subsequently transported to the vacuole for clearance, likely via autophagy. This pathway selectively eliminates mRNAs before metaphase I, including

Indexed as

Antisense RNAAutophagyDouble-stranded RNAMeiosisProgrammed mRNA DegradationTranscription factorVacuole

Identifiers

PMID41648114
PMCPMC12871743

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.