Evidence map›Paper›PMID 41648188›Full record

ArticlebioRxiv : the preprint server for biology2026

EpiBrain: the brain's epigenetic landscape in a snapshot.

Maja Johnson, Aiden F Eno, Karl Stuntzner-Gibson, James W MacDonald, Theo K Bammler, Yijie Geng

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maja JohnsonDepartment of Environmental and Occupational Health Sciences, Seattle, WA 98105, USA.
Aiden F EnoDepartment of Environmental and Occupational Health Sciences, Seattle, WA 98105, USA.
Karl Stuntzner-GibsonDepartment of Environmental and Occupational Health Sciences, Seattle, WA 98105, USA.
James W MacDonaldDepartment of Environmental and Occupational Health Sciences, Seattle, WA 98105, USA.
Theo K BammlerDepartment of Environmental and Occupational Health Sciences, Seattle, WA 98105, USA.
Yijie GengDepartment of Environmental and Occupational Health Sciences, Seattle, WA 98105, USA.

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
A systematic study of the environmental etiology of autism spectrum disorder using high-throughput behavioral screeningR00ES031050 · NIEHS · UNIVERSITY OF WASHINGTON · PI GENG, YIJIE · 2023 to 2025
$969k
NIDA NIH HHS P30 DA048736NIEHS NIH HHS R00 ES031050
6 · The paper itself

Abstract

Epigenetics connect nature with nurture and can help explain how genes, experiences, and the environment influence gene expression to promote individual differences in behavior and mental health. However, how these perturbations induce epigenetic changes across various regions of the brain remains largely unknown. To visualize changes in brain's epigenetic landscape at a glance, we develop EpiBrain, a method utilizing whole-brain imaging and registration to capture epigenetic changes in the entire zebrafish brain in a snapshot. Using this method, we uncovered brain-wide epigenetic changes induced by brain activity, chemical exposures, and genetic mutations. We found that

Identifiers

PMID41648188
PMCPMC12871645

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.