Evidence map›Paper›PMID 41648313›Full record

ArticlebioRxiv : the preprint server for biology2026

Intestinal Barrier Loss Enables Microbiota-Mediated Purinergic Suppression During Malaria.

Rafael B Polidoro, Olivia J Bednarski, Sawyer Lehman, Fabrício Marcus Silva Oliveira, Elizabeth M Fusco, Layne Bower, Marcos Rangel-Ferreira, Sukhmeet Kour, Ruth Namazzi, Robert O Opoka and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rafael B PolidoroRyan White Center for Pediatric Infectious Diseases and Global Health, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-2982-0072
Olivia J BednarskiRyan White Center for Pediatric Infectious Diseases and Global Health, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-3029-8461
Sawyer LehmanRyan White Center for Pediatric Infectious Diseases and Global Health, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Fabrício Marcus Silva OliveiraDepartment of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC 20052, USA.ORCID 0000-0001-9963-1758
Elizabeth M FuscoRyan White Center for Pediatric Infectious Diseases and Global Health, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2972-4657
Layne BowerRyan White Center for Pediatric Infectious Diseases and Global Health, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0009-0006-3650-2792
Marcos Rangel-FerreiraRyan White Center for Pediatric Infectious Diseases and Global Health, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Sukhmeet KourSchool of Science, Indiana University Indianapolis, IN 46202 USA.
Ruth NamazziDepartment of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda.ORCID 0000-0003-2459-6526
Robert O OpokaAga Khan University East Africa Medical College, Nairobi, Kenya.ORCID 0000-0003-3240-2058
Chandy JohnRyan White Center for Pediatric Infectious Diseases and Global Health, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-1634-1411
Jeffrey J BraultIndiana Center for Musculoskeletal Health, Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-3503-0528
Andrew Tilston-LunelRyan White Center for Pediatric Infectious Diseases and Global Health, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-5582-6884
José Carlos Alves-FilhoDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.ORCID 0000-0002-9918-8714
Nathan W SchmidtRyan White Center for Pediatric Infectious Diseases and Global Health, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-7325-4536

Funding

Indiana Clinical and Translational Sciences InstituteUM1TR004402 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI Sharon M Moe, Sarah Elizabeth Wiehe · 2023 to 2026
$21.6M
Severe Malaria And Risk to The Brain (SMART Brain)R01NS055349 · NINDS · UNIVERSITY OF MINNESOTA · PI Chandy C. John, Ruth Namazzi · 2008 to 2026
$11.2M
cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Gut microbiota and human malariaR01AI148525 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI JOHN, CHANDY C., SCHMIDT, NATHAN · 2020 to 2024
$3.6M
Role of the Gut Microbiota in Shaping Severity of MalariaR01AI183911 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI Nathan Schmidt · 2024 to 2026
$2.3M
NCATS NIH HHS UM1 TR004402NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS R01 AI148525NIAID NIH HHS R01 AI183911NIDA NIH HHS 75N95020D00005NINDS NIH HHS R01 NS055349ORFDO NIH HHS 75N99020D00005
6 · The paper itself

Abstract

The gut microbiota shapes malaria immunity and disease severity, but the mechanisms underlying these effects remain unclear. In a murine model, susceptibility to

Indexed as

gut microbiotaintestinal barrier integritymalaria pathogenesispurinergic signalingregulatory T cells

Identifiers

PMID41648313
PMCPMC12871692

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.