In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
23 authors.
Delong LiMechanism of Cellular Quality Control, Max Planck Institute of Biophysics; 60438 Frankfurt am Main, Germany.ORCID 0009-0006-7900-489X Wenxin ZhangMechanism of Cellular Quality Control, Max Planck Institute of Biophysics; 60438 Frankfurt am Main, Germany.ORCID 0000-0002-7657-4495 Michaela MedinaDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute; La Jolla, CA 92037, USA.ORCID 0000-0001-6346-5137 Jan F M StukeDepartment of Theoretical Biophysics, Max Planck Institute of Biophysics; 60438 Frankfurt am Main, Germany.ORCID 0009-0007-5583-4941 Andre SchwarzDepartment of Synaptic Plasticity, Max Planck Institute for Brain Research; 60438 Frankfurt am Main, Germany.ORCID 0000-0003-0827-4957 Jonas BrillInstitute of Pharmaceutical Technology, Goethe University Frankfurt; 60438 Frankfurt am Main, Germany.
Johann BrennerMechanism of Cellular Quality Control, Max Planck Institute of Biophysics; 60438 Frankfurt am Main, Germany.ORCID 0000-0003-1306-3564 Felix KrausDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School; Boston, MA 02115, USA.ORCID 0000-0002-3757-541X Simon OhlerichMechanism of Cellular Quality Control, Max Planck Institute of Biophysics; 60438 Frankfurt am Main, Germany.
Javier LizarrondoMechanism of Cellular Quality Control, Max Planck Institute of Biophysics; 60438 Frankfurt am Main, Germany.ORCID 0000-0001-5199-4170 Jeremy PflaumMechanism of Cellular Quality Control, Max Planck Institute of Biophysics; 60438 Frankfurt am Main, Germany.ORCID 0009-0000-4878-8229 Julia H GrassMechanism of Cellular Quality Control, Max Planck Institute of Biophysics; 60438 Frankfurt am Main, Germany.ORCID 0009-0003-4698-5458 Lena-Marie SoltowMechanism of Cellular Quality Control, Max Planck Institute of Biophysics; 60438 Frankfurt am Main, Germany.
Dietmar HammerschmidProteomics and Mass Spectrometry, Max Planck Institute of Biophysics; 60438 Frankfurt am Main, Germany.ORCID 0000-0002-0210-3690 Natalie WeberProteomics and Mass Spectrometry, Max Planck Institute of Biophysics; 60438 Frankfurt am Main, Germany.
Sonja WelschCentral Electron Microscopy Facility, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.ORCID 0000-0002-6049-6664 Julian D LangerProteomics and Mass Spectrometry, Max Planck Institute of Biophysics; 60438 Frankfurt am Main, Germany.ORCID 0000-0002-5190-577X Maike WindbergsInstitute of Pharmaceutical Technology, Goethe University Frankfurt; 60438 Frankfurt am Main, Germany.ORCID 0000-0001-9475-699X J Wade HarperAligning Science Across Parkinson's (ASAP) Collaborative Research Network; Chevy Chase, MD 20815, USA.ORCID 0000-0002-6944-7236 Erin SchumanDepartment of Synaptic Plasticity, Max Planck Institute for Brain Research; 60438 Frankfurt am Main, Germany.ORCID 0000-0002-7053-1005 Gerhard HummerAligning Science Across Parkinson's (ASAP) Collaborative Research Network; Chevy Chase, MD 20815, USA.ORCID 0000-0001-7768-746X Danielle A GrotjahnDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute; La Jolla, CA 92037, USA.ORCID 0000-0001-5908-7882 Florian WilflingMechanism of Cellular Quality Control, Max Planck Institute of Biophysics; 60438 Frankfurt am Main, Germany.ORCID 0000-0002-6559-7261 Funding
Endolysosomal Proteome Landscapes Through the Lens of Neurodegenerative Risk AllelesR01NS110395 · NINDS · HARVARD MEDICAL SCHOOL · PI JEFFREY W HARPER · 2018 to 2026
$4.1MDefining Endoplasmic Reticulum Stress-Development Mitochondria RemodelingRF1NS125674 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI WISEMAN, ROCKLAND LUKE · 2022 to 2022
$2.4MDefining Endoplasmic Reticulum Stress-Development Mitochondria RemodelingR01NS125674 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI Rockland Luke Wiseman · 2025 to 2026
$1.4MNINDS NIH HHS R01 NS110395NINDS NIH HHS R01 NS125674NINDS NIH HHS RF1 NS125674
6 · The paper itselfAbstract
Lysosomal membrane integrity is essential for cellular homeostasis, and its failure drives lysosomal storage disorders (LSD) and neurodegeneration. The dipeptide L-leucyl-L-leucine methyl ester (LLOMe) is widely used to model lysosomal damage, yet its mechanism remains poorly understood. The prevailing view holds that LLOMe polymerizes into membrane-permeabilizing peptide chains within the lysosomal lumen. Using cryo-electron tomography in cultured cells and primary neurons, we visualized the structural basis of LLOMe-induced lysosomal damage. We reveal that LLOMe forms amyloid structures within lysosomes that directly interact with and rupture the limiting membrane through mechanical stress.
Identifiers
PMID41648416
PMCPMC12871838
What Socratic holds
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LicenceCC BY
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